Molecular determinants of drug resistance in tuberculosis

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Rapid detection of drug-resistant tuberculosis (TB) has become increasingly important in the era of pandemic human immunodeficiency virus infection and antibiotic resistance. The identification of the molecular correlates of antibiotic resistance in Mycobacterium tuberculosis have engendered the development of DNA-based assays for the identification of drug-resistant TB. This review summarizes the recent discoveries concerning resistance to isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, amikacin, kanamycin and the quinolones.

Original languageEnglish (US)
JournalInternational Journal of Tuberculosis and Lung Disease
Volume4
Issue number2 SUPPL. 1
StatePublished - Feb 2000

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Multidrug-Resistant Tuberculosis
Microbial Drug Resistance
Drug Resistance
Tuberculosis
Pyrazinamide
Ethambutol
Kanamycin
Amikacin
Quinolones
Isoniazid
Pandemics
Streptomycin
Virus Diseases
Rifampin
Mycobacterium tuberculosis
HIV
DNA

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Molecular determinants of drug resistance in tuberculosis. / Riska, P. F.; Jacobs, W. R.; Alland, D.

In: International Journal of Tuberculosis and Lung Disease, Vol. 4, No. 2 SUPPL. 1, 02.2000.

Research output: Contribution to journalArticle

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