TY - JOUR
T1 - Molecular damage in aging
AU - Gladyshev, Vadim N.
AU - Kritchevsky, Stephen B.
AU - Clarke, Steven G.
AU - Cuervo, Ana Maria
AU - Fiehn, Oliver
AU - de Magalhães, João Pedro
AU - Mau, Theresa
AU - Maes, Michal
AU - Moritz, Robert L.
AU - Niedernhofer, Laura J.
AU - Van Schaftingen, Emile
AU - Tranah, Gregory J.
AU - Walsh, Kenneth
AU - Yura, Yoshimitsu
AU - Zhang, Bohan
AU - Cummings, Steven R.
N1 - Publisher Copyright:
© 2021, Springer Nature America, Inc.
PY - 2021/12
Y1 - 2021/12
N2 - Cellular metabolism and environmental interactions generate molecular damage affecting all levels of biological organization. Accumulation of this damage over time is thought to have a central role in the aging process. Insufficient attention has been paid to the role of molecular damage in aging-related phenotypes, particularly in humans, in part because of the difficulty in measuring its various forms. Recently, omics approaches have been developed that begin to address this challenge, because they can assess a sizable proportion of age-related damage at the level of small molecules, proteins, RNA, DNA, organelles and cells. This Review describes the concept of molecular damage in aging and discusses its diverse aspects from theoretical models to experimental approaches. Measurement of multiple types of damage enables studies of the role of damage in aging and lays a foundation for testing interventions that reduce the burden of molecular damage, thereby targeting aging.
AB - Cellular metabolism and environmental interactions generate molecular damage affecting all levels of biological organization. Accumulation of this damage over time is thought to have a central role in the aging process. Insufficient attention has been paid to the role of molecular damage in aging-related phenotypes, particularly in humans, in part because of the difficulty in measuring its various forms. Recently, omics approaches have been developed that begin to address this challenge, because they can assess a sizable proportion of age-related damage at the level of small molecules, proteins, RNA, DNA, organelles and cells. This Review describes the concept of molecular damage in aging and discusses its diverse aspects from theoretical models to experimental approaches. Measurement of multiple types of damage enables studies of the role of damage in aging and lays a foundation for testing interventions that reduce the burden of molecular damage, thereby targeting aging.
UR - http://www.scopus.com/inward/record.url?scp=85130856700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130856700&partnerID=8YFLogxK
U2 - 10.1038/s43587-021-00150-3
DO - 10.1038/s43587-021-00150-3
M3 - Review article
AN - SCOPUS:85130856700
SN - 2662-8465
VL - 1
SP - 1096
EP - 1106
JO - Nature Aging
JF - Nature Aging
IS - 12
ER -