Molecular cytogenetics of mouse models of breast cancer

Thomas Ried, Kathy Dorritie, Zoë Weaver, Danny Wangsa, Michael J. Difilippantonio, Cristina Montagna

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In summary, the comprehensive molecular cytogenetic analysis of mouse models of breast cancers has shown that tumorigenesis requires, as in human cancers, the acquisition of distinct genomic imbalances. Some of these imbalances are common to all analyzed mouse models, such as frequent copy number losses on chromosome 4. However, distinct differences exist as well. The projection of the maps of genomic imbalances identified in human breast carcinomas onto the mouse genome shows that a considerable proportion of genomic imbalances occur in both species, however, the comparative maps do not result in "mirror" images of genomic imbalances. That being said, the BRCA1-associated mouse tumors reveal a distribution of genomic imbalances and a level of genomic instability that is most similar to human breast cancers.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalBreast Disease
Volume19
StatePublished - 2004
Externally publishedYes

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Cytogenetics
Breast Neoplasms
Chromosomes, Human, Pair 4
Genomic Instability
Cytogenetic Analysis
Neoplasms
Carcinogenesis
Genome

ASJC Scopus subject areas

  • Surgery

Cite this

Ried, T., Dorritie, K., Weaver, Z., Wangsa, D., Difilippantonio, M. J., & Montagna, C. (2004). Molecular cytogenetics of mouse models of breast cancer. Breast Disease, 19, 59-67.

Molecular cytogenetics of mouse models of breast cancer. / Ried, Thomas; Dorritie, Kathy; Weaver, Zoë; Wangsa, Danny; Difilippantonio, Michael J.; Montagna, Cristina.

In: Breast Disease, Vol. 19, 2004, p. 59-67.

Research output: Contribution to journalArticle

Ried, T, Dorritie, K, Weaver, Z, Wangsa, D, Difilippantonio, MJ & Montagna, C 2004, 'Molecular cytogenetics of mouse models of breast cancer', Breast Disease, vol. 19, pp. 59-67.
Ried T, Dorritie K, Weaver Z, Wangsa D, Difilippantonio MJ, Montagna C. Molecular cytogenetics of mouse models of breast cancer. Breast Disease. 2004;19:59-67.
Ried, Thomas ; Dorritie, Kathy ; Weaver, Zoë ; Wangsa, Danny ; Difilippantonio, Michael J. ; Montagna, Cristina. / Molecular cytogenetics of mouse models of breast cancer. In: Breast Disease. 2004 ; Vol. 19. pp. 59-67.
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