Molecular characteristics of transitional cell carcinoma in childhood

Jurgen F. Linn, Isabelle Sesterhenne, Fathollah Mostofi, Mark P. Schoenberg

Research output: Contribution to journalArticle

Abstract

Transitional cell carcinoma of the bladder is rare in children and young adults with age below 30. The risk of recurrence or progression in these patients has been shown to be low. We analyzed specific cytogenetic characteristics of transitional cell carcinomas from children and young adults as well as the p53 status of these tumors by immunohistochemistry. Seventeen patients diagnosed with transitional cell carcinoma of the urinary bladder before the age of 30 years underwent transurethral resection. Formalin-fixed, paraffin-embedded tumor specimens were sectioned and assay by in situ hybridization with centromeric probes to chromosomes 17 and y. In addition, immunohistochemistry staining for the p53 tumor suppressor gene product was performed. Four of 17 patients demonstrated aneuploidy of chromosome 17. Three of six patient demonstrated aneuploidy of chromosome y. Eleven of 17 tumors had nuclear accumulation of p53 gene product consistent with p53 gene mutation. previous investigators have hypothesized that bladder carcinomas in childhood are biologically different than tumors that occur later in life, our data suggest that mutation of p53 tumor suppressor gene is relatively common among patients with bladder carcinomas occurring before the age of 30. Aneuploidy of chromosome y and 17 is rare in childhood bladder cancer. These data support the notion that superficial transitional carcinoma occurring in young adults may have different molecular antecedents than occurring in the adult population.

Original languageEnglish (US)
Pages (from-to)73
Number of pages1
JournalBritish Journal of Urology
Volume80
Issue numberSUPPL. 2
StatePublished - 1997
Externally publishedYes

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Transitional Cell Carcinoma
Chromosomes, Human, Pair 17
Urinary Bladder
Aneuploidy
Young Adult
p53 Genes
Tumor Suppressor Genes
Carcinoma
Neoplasms
Immunohistochemistry
Mutation
Urinary Bladder Neoplasms
Cytogenetics
Paraffin
Formaldehyde
In Situ Hybridization
Chromosomes
Research Personnel
Staining and Labeling
Recurrence

ASJC Scopus subject areas

  • Urology

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Molecular characteristics of transitional cell carcinoma in childhood. / Linn, Jurgen F.; Sesterhenne, Isabelle; Mostofi, Fathollah; Schoenberg, Mark P.

In: British Journal of Urology, Vol. 80, No. SUPPL. 2, 1997, p. 73.

Research output: Contribution to journalArticle

Linn, JF, Sesterhenne, I, Mostofi, F & Schoenberg, MP 1997, 'Molecular characteristics of transitional cell carcinoma in childhood', British Journal of Urology, vol. 80, no. SUPPL. 2, pp. 73.
Linn, Jurgen F. ; Sesterhenne, Isabelle ; Mostofi, Fathollah ; Schoenberg, Mark P. / Molecular characteristics of transitional cell carcinoma in childhood. In: British Journal of Urology. 1997 ; Vol. 80, No. SUPPL. 2. pp. 73.
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