Molecular and clinical response to angiotensin II receptor antagonist in kidney transplant patients with chronic allograft nephropathy

Valeria R. Mas, Teresita Alvarellos, Daniel G. Maluf, Andrea Ferreira-Gonzalez, Liliana Oliveros, Rafael A. Maldonado, Graciela De Boccardo

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Chronic allograft nephropathy (CAN) represents an important cause of graft loss after kidney transplantation. TGF-β1 is a key factor in fibrogenesis, and the angiotensin II receptor antagonist losartan may decrease the intra-graft synthesis of TGF-β1. The aim of this study was to determine the clinical and molecular effect of losartan in kidney transplant patients (KTPs) with CAN. We studied nine KTPs, after the first year of transplantation, with proteinuria (more than 500 mg/24 h), stable renal function, and histological signs of CAN. Immunosuppression was cyclosporine, azathioprine, and corticoids. Kidney biopsy was performed in all patients at the beginning of the study and 12 weeks after treatment with 50 mg/day of losartan. Quantitation of intra-graft expression of TGF-β1 was performed in all biopsies, by real-time PCR. After losartan treatment there were no differences in patients' BP and blood creatinine level. The proteinuria significantly dropped to 414.2 ± 377 mg/24 h, P = 0.001. Intra-graft expression of TGF-β1 was decreased after treatment. In conclusion, losartan significantly decreases the intra-graft expression of TGF-β1 and proteinuria in KTPs with CAN.

Original languageEnglish (US)
Pages (from-to)540-544
Number of pages5
JournalTransplant International
Volume17
Issue number9
DOIs
StatePublished - Oct 1 2004

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Keywords

  • Angiotensin II
  • Angiotensin II receptor antagonist
  • Chronic allograft nephropathy
  • Kidney transplantation
  • Losartan
  • TGF-β1

ASJC Scopus subject areas

  • Transplantation

Cite this

Mas, V. R., Alvarellos, T., Maluf, D. G., Ferreira-Gonzalez, A., Oliveros, L., Maldonado, R. A., & De Boccardo, G. (2004). Molecular and clinical response to angiotensin II receptor antagonist in kidney transplant patients with chronic allograft nephropathy. Transplant International, 17(9), 540-544. https://doi.org/10.1007/s00147-004-0740-5