Modulations in oscillatory activity of globus pallidus internus neurons during a directed hand movement task—A primary mechanism for motor planning

Shreya Saxena, Sridevi V. Sarma, Shaun R. Patel, Sabato Santaniello, Emad N. Eskandar, John T. Gale

Research output: Contribution to journalArticle

Abstract

Globus pallidus internus (GPi) neurons in the basal ganglia are traditionally thought to play a significant role in the promotion and suppression of movement via a change in firing rates. Here, we hypothesize that a primary mechanism of movement control by GPi neurons is through specific modulations in their oscillatory patterns. We analyzed neuronal spiking activity of 83 GPi neurons recorded from two healthy nonhuman primates executing a radial center-out motor task. We found that, in directionally tuned neurons, the power in the gamma band is significantly (p < 0.05) greater than that in the beta band (a “cross-over” effect), during the planning stages of movements in their preferred direction. This cross-over effect is not observed in the non-directionally tuned neurons. These data suggest that, during movement planning, information encoding by GPi neurons may be governed by a sudden emergence and suppression of oscillatory activities, rather than simply by a change in average firing rates.

Original languageEnglish (US)
Article number15
JournalFrontiers in Systems Neuroscience
Volume13
DOIs
StatePublished - Apr 16 2019

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Globus Pallidus
Hand
Neurons
Basal Ganglia
Primates

Keywords

  • Basal ganglia
  • Beta-band
  • Globus pallidus internus (GPi)
  • Motor control
  • Movement planning

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Modulations in oscillatory activity of globus pallidus internus neurons during a directed hand movement task—A primary mechanism for motor planning. / Saxena, Shreya; Sarma, Sridevi V.; Patel, Shaun R.; Santaniello, Sabato; Eskandar, Emad N.; Gale, John T.

In: Frontiers in Systems Neuroscience, Vol. 13, 15, 16.04.2019.

Research output: Contribution to journalArticle

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