Modulation of plasminogen activator activity in human skin fibroblasts infected with mycoplasmas

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Abstract

Secreted and cell-associated plasminogen activator was measured in human skin fibroblasts infected with mycoplasmas. The infected fibroblasts exhibited significantly higher levels of secreted and cell-associated plasminogen activator activity compared to uninfected skin fibroblasts. Subconfluent infected fibroblasts had increased plasminogen activator activity compared to confluent infected fibroblasts. Plasminogen activator may be important in tissue destruction in disease states in which mycoplasma infection has been implicated.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume173
Issue number3
StatePublished - 1983

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Mycoplasma
Plasminogen Activators
Fibroblasts
Human Activities
Skin
Modulation
Mycoplasma Infections
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Modulation of plasminogen activator activity in human skin fibroblasts infected with mycoplasmas",
abstract = "Secreted and cell-associated plasminogen activator was measured in human skin fibroblasts infected with mycoplasmas. The infected fibroblasts exhibited significantly higher levels of secreted and cell-associated plasminogen activator activity compared to uninfected skin fibroblasts. Subconfluent infected fibroblasts had increased plasminogen activator activity compared to confluent infected fibroblasts. Plasminogen activator may be important in tissue destruction in disease states in which mycoplasma infection has been implicated.",
author = "Hatcher, {Victor Bernard}",
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AB - Secreted and cell-associated plasminogen activator was measured in human skin fibroblasts infected with mycoplasmas. The infected fibroblasts exhibited significantly higher levels of secreted and cell-associated plasminogen activator activity compared to uninfected skin fibroblasts. Subconfluent infected fibroblasts had increased plasminogen activator activity compared to confluent infected fibroblasts. Plasminogen activator may be important in tissue destruction in disease states in which mycoplasma infection has been implicated.

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