Modulation of lipopolysaccharide-induced tumor necrosis factor-α and nitric oxide production by dopamine receptor agonists and antagonists in mice

G. Haskó, C. Szabó, K. Merkel, A. Bencsics, B. Zingarelli, V. Kvetan, E. S. Vizi

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The effects of various agonists and antagonists of dopamine D1 and D2 receptors on lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) and nitric oxide (NO) production was investigated in mice. Pretreatment of animals with bromocryptine or quinpirole, agonists of dopamine D2 receptors caused a blunting of both the TNF-α and MO responses to LPS injected intraperitoneally. Sulpiride, an antagonist of dopamine D2 receptors, decreased the LPS-induced TNF-α plasma levels in a dose-dependent manner and inhibited the LPS-induced NO production by peritoneal macrophages. Bromocryptine or quinpirole blunted both the TNF-α and NO response to LPS. SCH-23390, an antagonist of dopamine D1 receptors did not alter LPS-induced TNF-α production, but inhibited LPS-induced NO production. These results indicate that while the D2 subtype of dopamine receptors is involved in the modulation of both LPS-induced TNF-α and NO production, dopamine D1 receptors only regulate the production of NO. Since several drugs possess effect on dopamine D2 receptors, the present observations may be of clinical relevance.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalImmunology Letters
Volume49
Issue number3
DOIs
StatePublished - Mar 1996

Keywords

  • Bromocryptine
  • Dopamine D receptors
  • Dopamine D receptors
  • Lipopolysaccharide-induced tumor necrosis factor-α
  • SCH-23390
  • Sulpiride

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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