Modulation of K+ channel currents by serum amineoxidase in neurons

Lingyun Wu, Mircea Alexandru Mateescu, Xintao Wang, Bruno Mondovi, Rui Wang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The influence of bovine serum amineoxidase (SAO), a circulating copper-enzyme, on neuronal K+ channels is described. Bovine SAO enhanced K+ channel currents in N1E-115 neuroblastoma cells in a time-dependent manner. Unlike ceruloplasmin (another copper-protein, shown as depolarizing factor in neurons), SAO had no effect on resting potential of neurons. However, pretreatment of cells with SAO inhibited ceruloplasmin-induced membrane depolarization. Although ceruloplasmin alone inhibited K+ channel currents, it further enhanced K+ channel currents in the presence of SAO. Therefore, SAO may be another endogenous modulator of neuronal K+ channels with effect and mechanisms different from those of ceruloplasmin.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume220
Issue number1
DOIs
StatePublished - Mar 7 1996
Externally publishedYes

Fingerprint

Ceruloplasmin
Neurons
Modulation
Serum
Copper
Depolarization
Modulators
Cells
Membranes
Neuroblastoma
Membrane Potentials
Enzymes
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Modulation of K+ channel currents by serum amineoxidase in neurons. / Wu, Lingyun; Mateescu, Mircea Alexandru; Wang, Xintao; Mondovi, Bruno; Wang, Rui.

In: Biochemical and Biophysical Research Communications, Vol. 220, No. 1, 07.03.1996, p. 47-52.

Research output: Contribution to journalArticle

Wu, Lingyun ; Mateescu, Mircea Alexandru ; Wang, Xintao ; Mondovi, Bruno ; Wang, Rui. / Modulation of K+ channel currents by serum amineoxidase in neurons. In: Biochemical and Biophysical Research Communications. 1996 ; Vol. 220, No. 1. pp. 47-52.
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