Modulation of gap junction channels and hemichannels by growth factors

Kurt A. Schalper, Manuel A. Riquelme, María C. Brañes, Agustín D. Martínez, José Luis Vega, Viviana M. Berthoud, Michael V. L. Bennett, Juan C. Sáez

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Gap junction hemichannels and cell-cell channels have roles in coordinating numerous cellular processes, due to their permeability to extra and intracellular signaling molecules. Another mechanism of cellular coordination is provided by a vast array of growth factors that interact with relatively selective cell membrane receptors. These receptors can affect cellular transduction pathways, including alteration of intracellular concentration of free Ca 2+ and free radicals and activation of protein kinases or phosphatases. Connexin and pannexin based channels constitute recently described targets of growth factor signal transduction pathways, but little is known regarding the effects of growth factor signaling on pannexin based channels. The effects of growth factors on these two channel types seem to depend on the cell type, cell stage and connexin and pannexin isoform expressed. The functional state of hemichannels and gap junction channels are affected in opposite directions by FGF-1 via protein kinase-dependent mechanisms. These changes are largely explained by channels insertion in or withdrawal from the cell membrane, but changes in open probability might also occur due to changes in phosphorylation and redox state of channel subunits. The functional consequence of variation in cell-cell communication via these membrane channels is implicated in disease as well as normal cellular responses.

Original languageEnglish (US)
Pages (from-to)685-698
Number of pages14
JournalMolecular BioSystems
Volume8
Issue number3
DOIs
StatePublished - Mar 2012

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Gap Junctions
Intercellular Signaling Peptides and Proteins
Connexins
Protein Kinases
Cell Membrane
Fibroblast Growth Factor 1
Phosphoprotein Phosphatases
Ion Channels
Cell Communication
Oxidation-Reduction
Free Radicals
Permeability
Signal Transduction
Protein Isoforms
Phosphorylation

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

Cite this

Schalper, K. A., Riquelme, M. A., Brañes, M. C., Martínez, A. D., Vega, J. L., Berthoud, V. M., ... Sáez, J. C. (2012). Modulation of gap junction channels and hemichannels by growth factors. Molecular BioSystems, 8(3), 685-698. https://doi.org/10.1039/c1mb05294b

Modulation of gap junction channels and hemichannels by growth factors. / Schalper, Kurt A.; Riquelme, Manuel A.; Brañes, María C.; Martínez, Agustín D.; Vega, José Luis; Berthoud, Viviana M.; Bennett, Michael V. L.; Sáez, Juan C.

In: Molecular BioSystems, Vol. 8, No. 3, 03.2012, p. 685-698.

Research output: Contribution to journalArticle

Schalper, KA, Riquelme, MA, Brañes, MC, Martínez, AD, Vega, JL, Berthoud, VM, Bennett, MVL & Sáez, JC 2012, 'Modulation of gap junction channels and hemichannels by growth factors', Molecular BioSystems, vol. 8, no. 3, pp. 685-698. https://doi.org/10.1039/c1mb05294b
Schalper KA, Riquelme MA, Brañes MC, Martínez AD, Vega JL, Berthoud VM et al. Modulation of gap junction channels and hemichannels by growth factors. Molecular BioSystems. 2012 Mar;8(3):685-698. https://doi.org/10.1039/c1mb05294b
Schalper, Kurt A. ; Riquelme, Manuel A. ; Brañes, María C. ; Martínez, Agustín D. ; Vega, José Luis ; Berthoud, Viviana M. ; Bennett, Michael V. L. ; Sáez, Juan C. / Modulation of gap junction channels and hemichannels by growth factors. In: Molecular BioSystems. 2012 ; Vol. 8, No. 3. pp. 685-698.
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