TY - JOUR
T1 - Modulation of cortical circuits by top-down processing and arousal state in health and disease
AU - Batista-Brito, Renata
AU - Zagha, Edward
AU - Ratliff, Jacob M.
AU - Vinck, Martin
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/10
Y1 - 2018/10
N2 - In this review, we explore how contextual modulations of sensory processing are implemented within the local cortical circuit. We focus on contextual influences of global arousal state (e.g. how alert am I?), sensory predictions (e.g. which stimuli do I expect?), and top-down attention (what is relevant to me?). We review recent literature suggesting that these operations are implemented throughout sensory cortices, and are mediated by excitatory and inhibitory local circuits. By focusing on the circuit mechanisms of contextual modulation operations, we may begin to understand how mutations in GABAergic interneurons and alterations in neuromodulatory signaling lead to specific deficits of information processing in neuropsychiatric disease.
AB - In this review, we explore how contextual modulations of sensory processing are implemented within the local cortical circuit. We focus on contextual influences of global arousal state (e.g. how alert am I?), sensory predictions (e.g. which stimuli do I expect?), and top-down attention (what is relevant to me?). We review recent literature suggesting that these operations are implemented throughout sensory cortices, and are mediated by excitatory and inhibitory local circuits. By focusing on the circuit mechanisms of contextual modulation operations, we may begin to understand how mutations in GABAergic interneurons and alterations in neuromodulatory signaling lead to specific deficits of information processing in neuropsychiatric disease.
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U2 - 10.1016/j.conb.2018.06.008
DO - 10.1016/j.conb.2018.06.008
M3 - Review article
C2 - 30064117
AN - SCOPUS:85050615471
SN - 0959-4388
VL - 52
SP - 172
EP - 181
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -