Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver

Yi Zhang, Yabin Wang, Aijuan Liu, Sherry Li Xu, Bin Zhao, Yi Zhang, Hanfa Zou, Wenyi Wang, Hao Zhu, Bing Yan

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The liver plays an important role in metabolizing foreign materials, such as drugs. The high accumulation of carbon nanotubes and other hydrophobic nanoparticles in the liver has raised concerns that nanoparticles may interfere with liver metabolic function. We report here that carbon nanotubes enter hepatic cells after intravenous introduction and interact with CYP enzymes, including CYP3A4. Surface chemical modifications alter the carbon nanotubes' interactions with CYP450 enzymes in human liver microsomes. They enhance, inhibit, or have no effect on the enzymatic function of CYP3A4. Using a cheminformatics analysis, certain chemical structures are identified on the surface of the carbon nanotubes that induce an enzyme inhibitory effect or prevent disruption of CYP3A4 enzymes.

Original languageEnglish (US)
Pages (from-to)841-850
Number of pages10
JournalAdvanced Functional Materials
Volume26
Issue number6
DOIs
StatePublished - Feb 9 2016
Externally publishedYes

Keywords

  • CYP450
  • combinatorial chemistry
  • functionalized MWCNTs
  • human liver microsome
  • pharmacophores

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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    Zhang, Y., Wang, Y., Liu, A., Xu, S. L., Zhao, B., Zhang, Y., Zou, H., Wang, W., Zhu, H., & Yan, B. (2016). Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver. Advanced Functional Materials, 26(6), 841-850. https://doi.org/10.1002/adfm.201504182