Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver

Yi Zhang, Yabin Wang, Aijuan Liu, Sherry Li Xu, Bin Zhao, Yi Zhang, Hanfa Zou, Wenyi Wang, Hao Zhu, Bing Yan

Research output: Contribution to journalArticle

Abstract

The liver plays an important role in metabolizing foreign materials, such as drugs. The high accumulation of carbon nanotubes and other hydrophobic nanoparticles in the liver has raised concerns that nanoparticles may interfere with liver metabolic function. We report here that carbon nanotubes enter hepatic cells after intravenous introduction and interact with CYP enzymes, including CYP3A4. Surface chemical modifications alter the carbon nanotubes' interactions with CYP450 enzymes in human liver microsomes. They enhance, inhibit, or have no effect on the enzymatic function of CYP3A4. Using a cheminformatics analysis, certain chemical structures are identified on the surface of the carbon nanotubes that induce an enzyme inhibitory effect or prevent disruption of CYP3A4 enzymes.

Original languageEnglish (US)
Pages (from-to)841-850
Number of pages10
JournalAdvanced Functional Materials
Volume26
Issue number6
DOIs
StatePublished - Feb 9 2016
Externally publishedYes

Fingerprint

yarns
Biochips
bioassay
Bioassay
Chemical modification
metabolism
Microarrays
chemical analysis
liver
Metabolism
Liver
Nanotubes
Yarn
enzymes
Carbon nanotubes
nanotubes
Enzymes
carbon nanotubes
Modulation
Nanoparticles

Keywords

  • combinatorial chemistry
  • CYP450
  • functionalized MWCNTs
  • human liver microsome
  • pharmacophores

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver. / Zhang, Yi; Wang, Yabin; Liu, Aijuan; Xu, Sherry Li; Zhao, Bin; Zhang, Yi; Zou, Hanfa; Wang, Wenyi; Zhu, Hao; Yan, Bing.

In: Advanced Functional Materials, Vol. 26, No. 6, 09.02.2016, p. 841-850.

Research output: Contribution to journalArticle

Zhang, Y, Wang, Y, Liu, A, Xu, SL, Zhao, B, Zhang, Y, Zou, H, Wang, W, Zhu, H & Yan, B 2016, 'Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver', Advanced Functional Materials, vol. 26, no. 6, pp. 841-850. https://doi.org/10.1002/adfm.201504182
Zhang, Yi ; Wang, Yabin ; Liu, Aijuan ; Xu, Sherry Li ; Zhao, Bin ; Zhang, Yi ; Zou, Hanfa ; Wang, Wenyi ; Zhu, Hao ; Yan, Bing. / Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver. In: Advanced Functional Materials. 2016 ; Vol. 26, No. 6. pp. 841-850.
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