Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-ε4 allele in Latin Americans: Findings from the Maracaibo Aging Study

Aldrin E. Molero, Gloria Pino-Ramírez, Gladys E. Maestre

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one ε4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-ε4, adjusted for age and stratified by gender, was significant only for women. No association was found between the ε-2 allele and AD or VD. The results support the notions that APOE-ε4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association.

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalNeuroscience Letters
Volume307
Issue number1
DOIs
StatePublished - Jul 6 2001
Externally publishedYes

Keywords

  • Apolipoprotein E
  • Caribbean
  • Dementia
  • Elderly
  • Population-based
  • Risk

ASJC Scopus subject areas

  • Neuroscience(all)

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