Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-ε4 allele in Latin Americans: Findings from the Maracaibo Aging Study

Aldrin E. Molero; Gloria Pino-Ramírez; Gladys E. Maestre

doi:10.1016/S0304-3940(01)01911-5

Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-ε4 allele in Latin Americans: Findings from the Maracaibo Aging Study

Aldrin E. Molero, Gloria Pino-Ramírez, Gladys E. Maestre

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one ε4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-ε4, adjusted for age and stratified by gender, was significant only for women. No association was found between the ε-2 allele and AD or VD. The results support the notions that APOE-ε4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association.

Original language	English (US)
Pages (from-to)	5-8
Number of pages	4
Journal	Neuroscience Letters
Volume	307
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(01)01911-5
State	Published - Jul 6 2001
Externally published	Yes

Keywords

Apolipoprotein E
Caribbean
Dementia
Elderly
Population-based
Risk

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(01)01911-5

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Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-ε4 allele in Latin Americans: Findings from the Maracaibo Aging Study. / Molero, Aldrin E.; Pino-Ramírez, Gloria; Maestre, Gladys E.
In: Neuroscience Letters, Vol. 307, No. 1, 06.07.2001, p. 5-8.

Research output: Contribution to journal › Article › peer-review

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title = "Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-ε4 allele in Latin Americans: Findings from the Maracaibo Aging Study",

abstract = "An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one ε4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-ε4, adjusted for age and stratified by gender, was significant only for women. No association was found between the ε-2 allele and AD or VD. The results support the notions that APOE-ε4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association.",

keywords = "Apolipoprotein E, Caribbean, Dementia, Elderly, Population-based, Risk",

author = "Molero, {Aldrin E.} and Gloria Pino-Ram{\'i}rez and Maestre, {Gladys E.}",

note = "Funding Information: Support for the present study was provided by CONICIT Grant G-97000726. B.S. Waleska Fulcado, Dr Alicex Gonz{\'a}lez, Glabenys Barroso, and Lizzie Ocando extracted the DNA and amplified APOE. Drs Mar{\'ı}a Nava, Ledys Mata, and Ida Julia Ojeda performed the neuropsychiatric evaluations; psychologists Sabrina Gonz{\'a}lez, Yulissa Dickson, Elvilena Passeri, and Mar{\'ı}a Jos{\'e} Machado conducted the neuropsychologic tests; and Ms. Mallira Rodr{\'ı}guez managed the database. We gratefully acknowledge their continuing efforts in the project and thank Drs Karen Marder and Tulio A. Sulbar{\'a}n for their support and encouragement. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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N2 - An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one ε4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-ε4, adjusted for age and stratified by gender, was significant only for women. No association was found between the ε-2 allele and AD or VD. The results support the notions that APOE-ε4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association.

AB - An ongoing longitudinal study in Maracaibo, Venezuela, examined the interaction between apolipoprotein E (APOE) genotypes and Alzheimer's disease (AD) and vascular dementia (VD), evaluating age and gender as potential modifiers of risk. Overall, carriers of at least one ε4 allele were at higher risk for AD, not for VD; however, the risk was significant only for subjects older than 65, and it increased 10-fold in subjects older than 85. The risk of AD conferred by APOE-ε4, adjusted for age and stratified by gender, was significant only for women. No association was found between the ε-2 allele and AD or VD. The results support the notions that APOE-ε4 is relevant for late-onset, not early onset AD, and that age and gender act as modulators of this association.

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Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-ε4 allele in Latin Americans: Findings from the Maracaibo Aging Study

Abstract

Keywords

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