Modular peptide recognition domains in eukaryotic signaling

John Kuriyan, David Cowburn

Research output: Contribution to journalReview articlepeer-review

234 Scopus citations


A characteristic feature of cellular signal transduction pathways in eukaryotes is the separation of catalysis from target recognition. Several modular domains that recognize short peptide sequences and target signaling proteins to these sequences have been identified. The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and these results are reviewed here. In addition, the mechanism of cooperative interactions between these domains is discussed.

Original languageEnglish (US)
Pages (from-to)259-288
Number of pages30
JournalAnnual Review of Biophysics and Biomolecular Structure
StatePublished - Jun 30 1997
Externally publishedYes


  • PDZ
  • PTB
  • SH2
  • SH3
  • Src homology
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology


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