Modifiers of epigenetic reprogramming show paternal effects in the mouse

Suyinn Chong; Nicola Vickaryous; Alyson Ashe; Natasha Zamudio; Neil Youngson; Sarah Hemley; Tomas Stopka; Arthur Skoultchi; Jacqui Matthews; Hamish S. Scott; David De Kretser; Moira O'Bryan; Marnie Blewitt; Emma Whitelaw

doi:10.1038/ng2031

Modifiers of epigenetic reprogramming show paternal effects in the mouse

Suyinn Chong, Nicola Vickaryous, Alyson Ashe, Natasha Zamudio, Neil Youngson, Sarah Hemley, Tomas Stopka, Arthur Skoultchi, Jacqui Matthews, Hamish S. Scott, David De Kretser, Moira O'Bryan, Marnie Blewitt, Emma Whitelaw

Cell Biology

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.

Original language	English (US)
Pages (from-to)	614-622
Number of pages	9
Journal	Nature Genetics
Volume	39
Issue number	5
DOIs	https://doi.org/10.1038/ng2031
State	Published - May 2007

ASJC Scopus subject areas

Genetics

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10.1038/ng2031

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title = "Modifiers of epigenetic reprogramming show paternal effects in the mouse",

abstract = "There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.",

author = "Suyinn Chong and Nicola Vickaryous and Alyson Ashe and Natasha Zamudio and Neil Youngson and Sarah Hemley and Tomas Stopka and Arthur Skoultchi and Jacqui Matthews and Scott, {Hamish S.} and {De Kretser}, David and Moira O'Bryan and Marnie Blewitt and Emma Whitelaw",

note = "Funding Information: This study was supported by National Health and Medical Research Council of Australia grants to E.W., D.D.K., H.S., J.M. and M.O{\textquoteright}B. and an Australian Research Council grant to S.C. and E.W. M.B., A.A. and N.Z. were supported by Australian Postgraduate Awards. N.V. was supported by an International Postgraduate Award (University of Sydney). N.Y. and E.W. were supported by fellowships from the Queensland Institute of Medical Research.",

year = "2007",

month = may,

doi = "10.1038/ng2031",

language = "English (US)",

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AU - Vickaryous, Nicola

AU - Ashe, Alyson

AU - Zamudio, Natasha

AU - Youngson, Neil

AU - Hemley, Sarah

AU - Stopka, Tomas

AU - Skoultchi, Arthur

AU - Matthews, Jacqui

AU - Scott, Hamish S.

AU - De Kretser, David

AU - O'Bryan, Moira

AU - Blewitt, Marnie

AU - Whitelaw, Emma

N1 - Funding Information: This study was supported by National Health and Medical Research Council of Australia grants to E.W., D.D.K., H.S., J.M. and M.O’B. and an Australian Research Council grant to S.C. and E.W. M.B., A.A. and N.Z. were supported by Australian Postgraduate Awards. N.V. was supported by an International Postgraduate Award (University of Sydney). N.Y. and E.W. were supported by fellowships from the Queensland Institute of Medical Research.

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AB - There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.

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Modifiers of epigenetic reprogramming show paternal effects in the mouse

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