Modification of the host epigenome by parasitic protists

Inessa Gendlina, Natalie Silmon de Monerri, Kami Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Protozoan parasites compose a large group of ubiquitous unicellular eukaryotic organisms that closely interact with, and frequently reside within, a larger host. These parasitic protists rely on their host for nutrients, energy, and biomaterials. The host–parasite interaction is complex, as parasites strive to achieve a delicate balance of survival and replication without inducing host death. The host, in turn, tries to protect itself by various means including activation of death pathways in order to limit parasite spread. Therefore, successful parasites have developed highly evolved tactics in order to avoid host immune recognition and intracellular killing and subvert the host to their needs. To this end, various mechanisms of hijacking of host processes via parasite-derived or secreted effectors have been described. It has recently come to light that parasites also induce alterations to the host epigenomic landscape. Changes in host DNA methylation, histone posttranslational modifications, nucleosome positioning, chromatin assembly, and regulation of transcription have been noted in the parasitized host. To date, only a few parasite-derived effectors have been shown to directly modify host chromatin, and it remains to be elucidated whether parasite-induced alterations to the host epigenomic landscape are brought on specifically by parasites or are due to the host response. Finally, while various parasites target different components of host epigenomic landscape, common themes in subversion of host pathways and process emerge. We aim to review what is known about parasite modulation of host epigenome and touch on some conserved themes in this host–parasite interplay.

Original languageEnglish (US)
Title of host publicationEpigenetics and Human Health
PublisherSpringer Verlag
Pages189-220
Number of pages32
Edition9783319550190
DOIs
StatePublished - 2017

Publication series

NameEpigenetics and Human Health
Number9783319550190
ISSN (Print)2191-2262
ISSN (Electronic)2191-2270

Fingerprint

Parasites
Epigenomics
Chromatin
Histone Code
Chromatin Assembly and Disassembly
Nucleosomes
Biocompatible Materials
DNA Methylation
Transcription
Post Translational Protein Processing
Histones
Nutrients
Chemical activation
Modulation
Food

Keywords

  • Chromatin remodeling
  • Cryptosporidium
  • DNA methylation
  • Eimeria
  • Epigenome
  • Histone
  • Host
  • Leishmania
  • Microsporidia
  • Noncoding RNA
  • Parasite
  • Plasmodium
  • Protist
  • Theileria
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Genetics

Cite this

Gendlina, I., Silmon de Monerri, N., & Kim, K. (2017). Modification of the host epigenome by parasitic protists. In Epigenetics and Human Health (9783319550190 ed., pp. 189-220). (Epigenetics and Human Health; No. 9783319550190). Springer Verlag. https://doi.org/10.1007/978-3-319-55021-3_9

Modification of the host epigenome by parasitic protists. / Gendlina, Inessa; Silmon de Monerri, Natalie; Kim, Kami.

Epigenetics and Human Health. 9783319550190. ed. Springer Verlag, 2017. p. 189-220 (Epigenetics and Human Health; No. 9783319550190).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gendlina, I, Silmon de Monerri, N & Kim, K 2017, Modification of the host epigenome by parasitic protists. in Epigenetics and Human Health. 9783319550190 edn, Epigenetics and Human Health, no. 9783319550190, Springer Verlag, pp. 189-220. https://doi.org/10.1007/978-3-319-55021-3_9
Gendlina I, Silmon de Monerri N, Kim K. Modification of the host epigenome by parasitic protists. In Epigenetics and Human Health. 9783319550190 ed. Springer Verlag. 2017. p. 189-220. (Epigenetics and Human Health; 9783319550190). https://doi.org/10.1007/978-3-319-55021-3_9
Gendlina, Inessa ; Silmon de Monerri, Natalie ; Kim, Kami. / Modification of the host epigenome by parasitic protists. Epigenetics and Human Health. 9783319550190. ed. Springer Verlag, 2017. pp. 189-220 (Epigenetics and Human Health; 9783319550190).
@inbook{bc76c4eae6964ccf917a7f0e3a2adfcd,
title = "Modification of the host epigenome by parasitic protists",
abstract = "Protozoan parasites compose a large group of ubiquitous unicellular eukaryotic organisms that closely interact with, and frequently reside within, a larger host. These parasitic protists rely on their host for nutrients, energy, and biomaterials. The host–parasite interaction is complex, as parasites strive to achieve a delicate balance of survival and replication without inducing host death. The host, in turn, tries to protect itself by various means including activation of death pathways in order to limit parasite spread. Therefore, successful parasites have developed highly evolved tactics in order to avoid host immune recognition and intracellular killing and subvert the host to their needs. To this end, various mechanisms of hijacking of host processes via parasite-derived or secreted effectors have been described. It has recently come to light that parasites also induce alterations to the host epigenomic landscape. Changes in host DNA methylation, histone posttranslational modifications, nucleosome positioning, chromatin assembly, and regulation of transcription have been noted in the parasitized host. To date, only a few parasite-derived effectors have been shown to directly modify host chromatin, and it remains to be elucidated whether parasite-induced alterations to the host epigenomic landscape are brought on specifically by parasites or are due to the host response. Finally, while various parasites target different components of host epigenomic landscape, common themes in subversion of host pathways and process emerge. We aim to review what is known about parasite modulation of host epigenome and touch on some conserved themes in this host–parasite interplay.",
keywords = "Chromatin remodeling, Cryptosporidium, DNA methylation, Eimeria, Epigenome, Histone, Host, Leishmania, Microsporidia, Noncoding RNA, Parasite, Plasmodium, Protist, Theileria, Toxoplasma gondii",
author = "Inessa Gendlina and {Silmon de Monerri}, Natalie and Kami Kim",
year = "2017",
doi = "10.1007/978-3-319-55021-3_9",
language = "English (US)",
series = "Epigenetics and Human Health",
publisher = "Springer Verlag",
number = "9783319550190",
pages = "189--220",
booktitle = "Epigenetics and Human Health",
edition = "9783319550190",

}

TY - CHAP

T1 - Modification of the host epigenome by parasitic protists

AU - Gendlina, Inessa

AU - Silmon de Monerri, Natalie

AU - Kim, Kami

PY - 2017

Y1 - 2017

N2 - Protozoan parasites compose a large group of ubiquitous unicellular eukaryotic organisms that closely interact with, and frequently reside within, a larger host. These parasitic protists rely on their host for nutrients, energy, and biomaterials. The host–parasite interaction is complex, as parasites strive to achieve a delicate balance of survival and replication without inducing host death. The host, in turn, tries to protect itself by various means including activation of death pathways in order to limit parasite spread. Therefore, successful parasites have developed highly evolved tactics in order to avoid host immune recognition and intracellular killing and subvert the host to their needs. To this end, various mechanisms of hijacking of host processes via parasite-derived or secreted effectors have been described. It has recently come to light that parasites also induce alterations to the host epigenomic landscape. Changes in host DNA methylation, histone posttranslational modifications, nucleosome positioning, chromatin assembly, and regulation of transcription have been noted in the parasitized host. To date, only a few parasite-derived effectors have been shown to directly modify host chromatin, and it remains to be elucidated whether parasite-induced alterations to the host epigenomic landscape are brought on specifically by parasites or are due to the host response. Finally, while various parasites target different components of host epigenomic landscape, common themes in subversion of host pathways and process emerge. We aim to review what is known about parasite modulation of host epigenome and touch on some conserved themes in this host–parasite interplay.

AB - Protozoan parasites compose a large group of ubiquitous unicellular eukaryotic organisms that closely interact with, and frequently reside within, a larger host. These parasitic protists rely on their host for nutrients, energy, and biomaterials. The host–parasite interaction is complex, as parasites strive to achieve a delicate balance of survival and replication without inducing host death. The host, in turn, tries to protect itself by various means including activation of death pathways in order to limit parasite spread. Therefore, successful parasites have developed highly evolved tactics in order to avoid host immune recognition and intracellular killing and subvert the host to their needs. To this end, various mechanisms of hijacking of host processes via parasite-derived or secreted effectors have been described. It has recently come to light that parasites also induce alterations to the host epigenomic landscape. Changes in host DNA methylation, histone posttranslational modifications, nucleosome positioning, chromatin assembly, and regulation of transcription have been noted in the parasitized host. To date, only a few parasite-derived effectors have been shown to directly modify host chromatin, and it remains to be elucidated whether parasite-induced alterations to the host epigenomic landscape are brought on specifically by parasites or are due to the host response. Finally, while various parasites target different components of host epigenomic landscape, common themes in subversion of host pathways and process emerge. We aim to review what is known about parasite modulation of host epigenome and touch on some conserved themes in this host–parasite interplay.

KW - Chromatin remodeling

KW - Cryptosporidium

KW - DNA methylation

KW - Eimeria

KW - Epigenome

KW - Histone

KW - Host

KW - Leishmania

KW - Microsporidia

KW - Noncoding RNA

KW - Parasite

KW - Plasmodium

KW - Protist

KW - Theileria

KW - Toxoplasma gondii

UR - http://www.scopus.com/inward/record.url?scp=85020042381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020042381&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-55021-3_9

DO - 10.1007/978-3-319-55021-3_9

M3 - Chapter

T3 - Epigenetics and Human Health

SP - 189

EP - 220

BT - Epigenetics and Human Health

PB - Springer Verlag

ER -