Models of Seizures and Epilepsy

Asla Pitkanen, Philip Schwartzkroin, Solomon L. Moshe

Research output: Book/ReportBook

144 Citations (Scopus)

Abstract

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.

Original languageEnglish (US)
PublisherElsevier Inc.
ISBN (Print)9780120885541
DOIs
StatePublished - 2006

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Epilepsy
Seizures
Explosions
Research
Molecular Biology
Research Personnel
Students
Physicians
Animals
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Models of Seizures and Epilepsy. / Pitkanen, Asla; Schwartzkroin, Philip; Moshe, Solomon L.

Elsevier Inc., 2006.

Research output: Book/ReportBook

Pitkanen, Asla ; Schwartzkroin, Philip ; Moshe, Solomon L. / Models of Seizures and Epilepsy. Elsevier Inc., 2006.
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