Abstract
We consider the relationship between accumulating exposure to a putative agent and the associated change in physiologic function. This type of problem is common to prospective studies of cognitive, pulmonary and cardiovascular function. A general model is proposed for data from prospective, observational studies with concurrent measures of exposures and continuous outcome measures. This model permits non-linearity in the relationship between exposure and outcome and is designed to describe outcome in terms of one's entire exposure history. As exposure data are often severely right-skewed, we use regression spline estimation methods which localize the influence of extreme points. We illustrate our methodology using data from a longitudinal epidemiologic investigation of the effects of amateur boxing on neuropsychologic function.
Original language | English (US) |
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Pages (from-to) | 2899-2916 |
Number of pages | 18 |
Journal | Statistics in Medicine |
Volume | 18 |
Issue number | 21 |
DOIs | |
State | Published - Nov 15 1999 |
Externally published | Yes |
ASJC Scopus subject areas
- Epidemiology
- Statistics and Probability