Modeling new therapies for infantile spasms

Lenka Chudomelova, Morris H. Scantlebury, Emmanuel Raffo, Antonietta Coppola, David Betancourth, Aristea S. Galanopoulou

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Infantile spasms are the classical seizure type of West syndrome. Infantile spasms often herald a dismal prognosis, due to the high probability to evolve into intractable forms of epilepsies with significant cognitive deficits, especially if not adequately treated. The current therapies - high doses of adrenocorticotropic hormone, steroids, or the γ-aminobutyric acid (GABA) transaminase inhibitor vigabatrin - are often toxic and may not always be effective. The need to identify new therapies for spasms has led to the generation of a number of rodent models of infantile spasms. These include acute and chronic models of infantile spasms, with cryptogenic or symptomatic origin, many of which are based on specific etiologies. In this review, we summarize the clinical experience with treating infantile spasms and the main features of the new animal models of infantile spasms and discuss their utility in the preclinical development of new therapies for infantile spasms.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalEpilepsia
Volume51
Issue numberSUPPL. 3
DOIs
StatePublished - Jul 2010

Keywords

  • Adrenocorticotropic hormone
  • Infantile spasms
  • Models
  • Rapamycin
  • Vigabatrin
  • mTOR

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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