Modeling neural spiking activity in the sub-thalamic nucleus of parkinson's patients and a healthy primate

Sridevi V. Sarma, Ming Cheng, Uri Eden, Rollin Hu, Ziv Williams, Emery N. Brown, Emad N. Eskandar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

How neurons encode information about the outside world and how this processing changes when the brain is diseased are central questions in neuroscience and medicine. Historically, microelectrode recordings of single-unit neuronal activity have been confined to animal preparations. Recently, it has become possible to obtain single-unit recordings in humans undergoing deep brain stimulation surgery. In this study, we recorded neuronal activity from the sub-thalamic nucleus (STN) of the basal ganglia of patients with Parkinson's disease (PD). In parallel, identical experiments were conducted on a healthy primate, providing a rare opportunity to analyze STN neuronal activity recorded in both the disease and healthy state during the same behavioral tasks. We developed point process models of STN neurons to capture neural spiking dynamics as a function of extrinsic stimuli and the neuron's own spiking history. Although our findings are preliminary due to only one primate subject, we found pathological signatures in PD neural activity (not found in the primate) such as bursting, 10-30Hz oscillations, and directional tuning prior to movement, which may directly relate to motor disorders observed in PD patients such as bradykinesia, resting tremor and rigidity.

Original languageEnglish (US)
Title of host publicationProceedings of the 47th IEEE Conference on Decision and Control, CDC 2008
Pages2012-2017
Number of pages6
DOIs
StatePublished - Dec 1 2008
Externally publishedYes
Event47th IEEE Conference on Decision and Control, CDC 2008 - Cancun, Mexico
Duration: Dec 9 2008Dec 11 2008

Other

Other47th IEEE Conference on Decision and Control, CDC 2008
CountryMexico
CityCancun
Period12/9/0812/11/08

Fingerprint

Parkinson's Disease
Nucleus
Neurons
Modeling
Neuron
Brain
Spiking Neurons
Unit
Bursting
Neuroscience
Microelectrodes
Point Process
Rigidity
Medicine
Surgery
Process Model
Disorder
Animals
Tuning
Preparation

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Modeling and Simulation
  • Control and Optimization

Cite this

Sarma, S. V., Cheng, M., Eden, U., Hu, R., Williams, Z., Brown, E. N., & Eskandar, E. N. (2008). Modeling neural spiking activity in the sub-thalamic nucleus of parkinson's patients and a healthy primate. In Proceedings of the 47th IEEE Conference on Decision and Control, CDC 2008 (pp. 2012-2017). [4738693] https://doi.org/10.1109/CDC.2008.4738693

Modeling neural spiking activity in the sub-thalamic nucleus of parkinson's patients and a healthy primate. / Sarma, Sridevi V.; Cheng, Ming; Eden, Uri; Hu, Rollin; Williams, Ziv; Brown, Emery N.; Eskandar, Emad N.

Proceedings of the 47th IEEE Conference on Decision and Control, CDC 2008. 2008. p. 2012-2017 4738693.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sarma, SV, Cheng, M, Eden, U, Hu, R, Williams, Z, Brown, EN & Eskandar, EN 2008, Modeling neural spiking activity in the sub-thalamic nucleus of parkinson's patients and a healthy primate. in Proceedings of the 47th IEEE Conference on Decision and Control, CDC 2008., 4738693, pp. 2012-2017, 47th IEEE Conference on Decision and Control, CDC 2008, Cancun, Mexico, 12/9/08. https://doi.org/10.1109/CDC.2008.4738693
Sarma SV, Cheng M, Eden U, Hu R, Williams Z, Brown EN et al. Modeling neural spiking activity in the sub-thalamic nucleus of parkinson's patients and a healthy primate. In Proceedings of the 47th IEEE Conference on Decision and Control, CDC 2008. 2008. p. 2012-2017. 4738693 https://doi.org/10.1109/CDC.2008.4738693
Sarma, Sridevi V. ; Cheng, Ming ; Eden, Uri ; Hu, Rollin ; Williams, Ziv ; Brown, Emery N. ; Eskandar, Emad N. / Modeling neural spiking activity in the sub-thalamic nucleus of parkinson's patients and a healthy primate. Proceedings of the 47th IEEE Conference on Decision and Control, CDC 2008. 2008. pp. 2012-2017
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