Modeling myeloid malignancies using zebrafish

Kathryn S. Potts, Teresa V. Bowman

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Human myeloid malignancies represent a substantial disease burden to individuals, with significant morbidity and death. The genetic underpinnings of disease formation and progression remain incompletely understood. Large-scale human population studies have identified a high frequency of potential driver mutations in spliceosomal and epigenetic regulators that contribute to malignancies, such as myelodysplastic syndromes (MDS) and leukemias. The high conservation of cell types and genes between humans and model organisms permits the investigation of the underlying mechanisms of leukemic development and potential therapeutic testing in genetically pliable pre-clinical systems. Due to the many technical advantages, such as large-scale screening, lineage-tracing studies, tumor transplantation, and high-throughput drug screening approaches, zebrafish is emerging as a model system for myeloid malignancies. In this review, we discuss recent advances in MDS and leukemia using the zebrafish model.

Original languageEnglish (US)
Article number297
JournalFrontiers in Oncology
Volume7
Issue numberDEC
DOIs
StatePublished - Dec 4 2017

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Keywords

  • Acute myeloid leukemia
  • Hematopoiesis
  • Malignancies
  • Myelodysplastic syndrome
  • Splicing
  • Zebrafish

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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