Modeling Dystonia-Parkinsonism

Diany Paola Calderon, Kamran Khodakhah

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dystonia and parkinsonism are symptoms often seen in multiple types of primary and secondary movement disorders. Studies of affected patients and different animal models indicate that parkinsonism and dystonia may be related anatomically, genetically, biochemically, and cellularly. These relationships among parkinsonism and dystonia may provide clues for determining the neural substrates and the pathological mechanisms that cause these diseases in isolation as well as other related disorders of motor control. The results of this type of analysis may offer therapeutic approaches to improve the condition of affected individuals.

Original languageEnglish (US)
Title of host publicationMovement Disorders
Subtitle of host publicationGenetics and Models: Second Edition
PublisherElsevier Inc.
Pages507-515
Number of pages9
ISBN (Print)9780124051959
DOIs
Publication statusPublished - Jan 1 2015

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Keywords

  • ATP1A3
  • Animal models
  • Basal ganglia
  • Cerebellum
  • DYT12
  • Dystonia
  • Parkinsonism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Calderon, D. P., & Khodakhah, K. (2015). Modeling Dystonia-Parkinsonism. In Movement Disorders: Genetics and Models: Second Edition (pp. 507-515). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405195-9.00029-9