Modeling Anaplastic Thyroid Carcinoma in the Mouse

Devora Champa, Antonio Di Cristofano

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Anaplastic thyroid carcinoma is the least common form of thyroid cancer; however, it accounts for the majority of deaths associated with this family of malignancies. A number of genetically engineered immunocompetent mouse models recapitulating the genetic and histological features of anaplastic thyroid cancer have been very recently generated and represent an invaluable tool to dissect the mechanisms involved in the progression from indolent, well-differentiated tumors to aggressive, undifferentiated carcinomas and to identify novel therapeutic targets. In this review, we focus on the relevant characteristics associated with these models and on what we have learned in terms of anaplastic thyroid cancer biology, genetics, and response to targeted therapy.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalHormones and Cancer
Volume6
Issue number1
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cancer Research

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