Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing

Daniel Lucas, Michela Battista, Patricia A. Shi, Luis Isola, Paul S. Frenette

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Endogenous rhythmicity likely evolved as a mechanism allowing organisms to anticipate predictable daily changes in the environment (Rutter et al., 2002). Under homeostasis, murine hematopoietic stem cell (HSC) egress is orchestrated by rhythmic β3 adrenergic signals delivered by the sympathetic nervous system (SNS) that regulate Cxcl12 expression in stromal cells (Mendez-Ferrer et al., 2008). Here, we show that CXCR4 is also regulated under circadian control whose rhythm is synchronized with its ligand, CXCL12, to optimize HSC trafficking. These circadian oscillations are inverted in humans compared to the mouse and continue to influence the yield even when stem cell mobilization is enforced. Our results suggest that the human HSC yield for clinical transplantation might be significantly greater if patients were harvested during the evening compared to the morning.

Original languageEnglish (US)
Pages (from-to)364-366
Number of pages3
JournalCell Stem Cell
Volume3
Issue number4
DOIs
StatePublished - Oct 9 2008
Externally publishedYes

Fingerprint

Hematopoietic Stem Cells
Hematopoietic Stem Cell Mobilization
Sympathetic Nervous System
Periodicity
Stromal Cells
Adrenergic Agents
Homeostasis
Transplantation
Ligands

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

Cite this

Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing. / Lucas, Daniel; Battista, Michela; Shi, Patricia A.; Isola, Luis; Frenette, Paul S.

In: Cell Stem Cell, Vol. 3, No. 4, 09.10.2008, p. 364-366.

Research output: Contribution to journalArticle

Lucas, Daniel ; Battista, Michela ; Shi, Patricia A. ; Isola, Luis ; Frenette, Paul S. / Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing. In: Cell Stem Cell. 2008 ; Vol. 3, No. 4. pp. 364-366.
@article{9bf5c962ea1745749ee24a98dbe34a40,
title = "Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing",
abstract = "Endogenous rhythmicity likely evolved as a mechanism allowing organisms to anticipate predictable daily changes in the environment (Rutter et al., 2002). Under homeostasis, murine hematopoietic stem cell (HSC) egress is orchestrated by rhythmic β3 adrenergic signals delivered by the sympathetic nervous system (SNS) that regulate Cxcl12 expression in stromal cells (Mendez-Ferrer et al., 2008). Here, we show that CXCR4 is also regulated under circadian control whose rhythm is synchronized with its ligand, CXCL12, to optimize HSC trafficking. These circadian oscillations are inverted in humans compared to the mouse and continue to influence the yield even when stem cell mobilization is enforced. Our results suggest that the human HSC yield for clinical transplantation might be significantly greater if patients were harvested during the evening compared to the morning.",
author = "Daniel Lucas and Michela Battista and Shi, {Patricia A.} and Luis Isola and Frenette, {Paul S.}",
year = "2008",
month = "10",
day = "9",
doi = "10.1016/j.stem.2008.09.004",
language = "English (US)",
volume = "3",
pages = "364--366",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing

AU - Lucas, Daniel

AU - Battista, Michela

AU - Shi, Patricia A.

AU - Isola, Luis

AU - Frenette, Paul S.

PY - 2008/10/9

Y1 - 2008/10/9

N2 - Endogenous rhythmicity likely evolved as a mechanism allowing organisms to anticipate predictable daily changes in the environment (Rutter et al., 2002). Under homeostasis, murine hematopoietic stem cell (HSC) egress is orchestrated by rhythmic β3 adrenergic signals delivered by the sympathetic nervous system (SNS) that regulate Cxcl12 expression in stromal cells (Mendez-Ferrer et al., 2008). Here, we show that CXCR4 is also regulated under circadian control whose rhythm is synchronized with its ligand, CXCL12, to optimize HSC trafficking. These circadian oscillations are inverted in humans compared to the mouse and continue to influence the yield even when stem cell mobilization is enforced. Our results suggest that the human HSC yield for clinical transplantation might be significantly greater if patients were harvested during the evening compared to the morning.

AB - Endogenous rhythmicity likely evolved as a mechanism allowing organisms to anticipate predictable daily changes in the environment (Rutter et al., 2002). Under homeostasis, murine hematopoietic stem cell (HSC) egress is orchestrated by rhythmic β3 adrenergic signals delivered by the sympathetic nervous system (SNS) that regulate Cxcl12 expression in stromal cells (Mendez-Ferrer et al., 2008). Here, we show that CXCR4 is also regulated under circadian control whose rhythm is synchronized with its ligand, CXCL12, to optimize HSC trafficking. These circadian oscillations are inverted in humans compared to the mouse and continue to influence the yield even when stem cell mobilization is enforced. Our results suggest that the human HSC yield for clinical transplantation might be significantly greater if patients were harvested during the evening compared to the morning.

UR - http://www.scopus.com/inward/record.url?scp=52949116088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52949116088&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2008.09.004

DO - 10.1016/j.stem.2008.09.004

M3 - Article

C2 - 18940728

AN - SCOPUS:52949116088

VL - 3

SP - 364

EP - 366

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 4

ER -