Abstract
Objective: Individuals with a diagnosis of multiple sclerosis (MS) often present with cognitive and motor deficits, and thus the ability to perform tasks that rely on both domains may be particularly impaired. Yet, dual-task walking studies yield mixed results. Individual variance in the ability to cope with brain insult and mobilize additional brain resources may contribute to mixed findings. Methods: To test this hypothesis, we acquired event-related potentials (ERP) in individuals with MS and healthy controls (HCs) performing a Go/NoGo task while sitting (i.e., single task) or walking (i.e., dual-task) and looked at the relationship between task related modulation of the brain response and performance. Results: On the Go/NoGo task the MS group showed dual-task costs when walking, whereas HCs showed a dual-task benefit. Further, whereas the HC group showed modulation of the brain response as a function of task load, this was not the case in the MS group. Analysis for the pooled sample revealed a positive correlation between load-related ERP effects and dual-task performance. Conclusions: These data suggest a neurophysiological marker of cognitive-motor dysfunction in MS. Significance: Understanding neural processes underlying dual-task walking will help identify objective brain measurements of real-world issues and may improve assessment of MS.
Original language | English (US) |
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Pages (from-to) | 1119-1128 |
Number of pages | 10 |
Journal | Clinical Neurophysiology |
Volume | 131 |
Issue number | 5 |
DOIs | |
State | Published - May 2020 |
Keywords
- Dual-task walking
- EEG
- Mobile Brain/Body Imaging (MoBI)
- Multiple sclerosis
ASJC Scopus subject areas
- Sensory Systems
- Neurology
- Clinical Neurology
- Physiology (medical)