Mixing insulin aspart with detemir does not affect glucose excursion in children with type 1 diabetes

Thanh M. Nguyen, Venkat S. Renukuntla, Rubina A. Heptulla

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

OBJECTIVE - We hypothesized that insulin detemir mixed with aspart had equivalent effects on blood glucose as if being given as separate injections in pediatric type 1 diabetes patients. RESEARCH DESIGN AND METHODS - Fourteen children with type 1 diabetes were randomly assigned to either Study A (mixed insulins) or Study B (separate insulins) for the first 10 days and crossed over for the last 10 days. Each subject underwent continuous glucose monitoring on the last 72 h of each study. RESULTS - The 48-h area under the curve (mmol/hour/l), M-value, and mean amplitude of glucose excursion (mmol/l) for Study A versus Study B were 457 ± 70 versus 469 ± 112 (P = 0.58), 39.67 ± 15.37 versus 39.75 ± 9.69 (P = 0.98), and 6.35 ± 1.92 versus 5.98 ± 0.92 (P = 0.42), respectively. CONCLUSIONS - Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.

Original languageEnglish (US)
Pages (from-to)1750-1752
Number of pages3
JournalDiabetes care
Volume33
Issue number8
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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