Mitral annulus size links ventricular dilatation to functional mitral regurgitation

Zoran B. Popović, Maureen Martin, Kiyotaka Fukamachi, Masahiro Inoue, Jun Kwan, Kazuyoshi Doi, Xin Qin Jian, Takahiro Shiota, Mario J. Garcia, Patrick M. McCarthy, James D. Thomas

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We compared the impact of annulus size and valve deformation (tethering) on mitral regurgitation in the animal dilated cardiomyopathy model, and assessed if acute left ventricular volume changes affect mitral annulus dimensions. We performed 3-dimensional echocardiography in 30 open-chest dogs with pacing-induced cardiomyopathy. Mitral annulus area was calculated from its two orthogonal diameters, whereas valve tethering was quantified by valve tenting area measurement. Mitral valve regurgitant volume showed the highest correlation with annulus area (r = 0.64, P < .001), left atrial volume (r = 0.40, P < .01), and left ventricular end-diastolic volume (r = 0.37, P < .01). Regurgitant volume showed poorer correlation with valve tethering in both septolateral and intercommissural planes (r = 0.35 and r = 0.31, P < .05 for both). Annulus dimensions correlated with acute changes of left ventricular end-diastolic volume (r = 0.68, P = .002). Mitral annulus dilation is the strongest predictor of functional mitral regurgitation in this animal dilated cardiomyopathy model.

Original languageEnglish (US)
Pages (from-to)959-963
Number of pages5
JournalJournal of the American Society of Echocardiography
Volume18
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

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Dilated Cardiomyopathy
Mitral Valve Insufficiency
Stroke Volume
Dilatation
Cardiomyopathies
Mitral Valve
Echocardiography
Thorax
Dogs

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Popović, Z. B., Martin, M., Fukamachi, K., Inoue, M., Kwan, J., Doi, K., ... Thomas, J. D. (2005). Mitral annulus size links ventricular dilatation to functional mitral regurgitation. Journal of the American Society of Echocardiography, 18(9), 959-963. https://doi.org/10.1016/j.echo.2005.01.011

Mitral annulus size links ventricular dilatation to functional mitral regurgitation. / Popović, Zoran B.; Martin, Maureen; Fukamachi, Kiyotaka; Inoue, Masahiro; Kwan, Jun; Doi, Kazuyoshi; Jian, Xin Qin; Shiota, Takahiro; Garcia, Mario J.; McCarthy, Patrick M.; Thomas, James D.

In: Journal of the American Society of Echocardiography, Vol. 18, No. 9, 09.2005, p. 959-963.

Research output: Contribution to journalArticle

Popović, ZB, Martin, M, Fukamachi, K, Inoue, M, Kwan, J, Doi, K, Jian, XQ, Shiota, T, Garcia, MJ, McCarthy, PM & Thomas, JD 2005, 'Mitral annulus size links ventricular dilatation to functional mitral regurgitation', Journal of the American Society of Echocardiography, vol. 18, no. 9, pp. 959-963. https://doi.org/10.1016/j.echo.2005.01.011
Popović, Zoran B. ; Martin, Maureen ; Fukamachi, Kiyotaka ; Inoue, Masahiro ; Kwan, Jun ; Doi, Kazuyoshi ; Jian, Xin Qin ; Shiota, Takahiro ; Garcia, Mario J. ; McCarthy, Patrick M. ; Thomas, James D. / Mitral annulus size links ventricular dilatation to functional mitral regurgitation. In: Journal of the American Society of Echocardiography. 2005 ; Vol. 18, No. 9. pp. 959-963.
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