Mitomycin‐C, methotrexate, bleomycin and cis‐diamminedichloroplatinum II in the chemotherapy of advanced squamous cancer of the head and neck

Steven E. Vogl, Harvey Lerner, Barry H. Kaplan, Fernando J. Camacho, James Cinberg, David Schoenfeld

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Thirty‐four patients with advanced squamous cancer of the head and neck were treated with an outpatient regimen combining mitomycin‐C, cis‐diamminedichloroplatinum (II), methotrexate and bleomycin. Five had complete remissions and 15 partial remissions, for an overall response rate of 59%. Responses were noted in 11 of 13 patients (85%) with disease above the clavicles without prior irradiation. Median duration of partial remission was four months. Response rate was independent of age, performance status, presence of distant metastases and primary site. Hematologic toxicity was substantially more severe with this program than had been observed in a prior study using the same regimen without mitomycin‐C. Since neither complete nor partial response rates, nor response durations improved with the addition of mitomycin, we conclude that it adds little to the efficacy of the other three agents.

Original languageEnglish (US)
Pages (from-to)6-9
Number of pages4
JournalCancer
Volume50
Issue number1
DOIs
StatePublished - Jan 1 1982

Fingerprint

Bleomycin
Head and Neck Neoplasms
Methotrexate
Drug Therapy
Clavicle
Mitomycin
Outpatients
Neoplasm Metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mitomycin‐C, methotrexate, bleomycin and cis‐diamminedichloroplatinum II in the chemotherapy of advanced squamous cancer of the head and neck. / Vogl, Steven E.; Lerner, Harvey; Kaplan, Barry H.; Camacho, Fernando J.; Cinberg, James; Schoenfeld, David.

In: Cancer, Vol. 50, No. 1, 01.01.1982, p. 6-9.

Research output: Contribution to journalArticle

Vogl, Steven E. ; Lerner, Harvey ; Kaplan, Barry H. ; Camacho, Fernando J. ; Cinberg, James ; Schoenfeld, David. / Mitomycin‐C, methotrexate, bleomycin and cis‐diamminedichloroplatinum II in the chemotherapy of advanced squamous cancer of the head and neck. In: Cancer. 1982 ; Vol. 50, No. 1. pp. 6-9.
@article{f7be1d97e9204dd282a06d8a8dee432c,
title = "Mitomycin‐C, methotrexate, bleomycin and cis‐diamminedichloroplatinum II in the chemotherapy of advanced squamous cancer of the head and neck",
abstract = "Thirty‐four patients with advanced squamous cancer of the head and neck were treated with an outpatient regimen combining mitomycin‐C, cis‐diamminedichloroplatinum (II), methotrexate and bleomycin. Five had complete remissions and 15 partial remissions, for an overall response rate of 59{\%}. Responses were noted in 11 of 13 patients (85{\%}) with disease above the clavicles without prior irradiation. Median duration of partial remission was four months. Response rate was independent of age, performance status, presence of distant metastases and primary site. Hematologic toxicity was substantially more severe with this program than had been observed in a prior study using the same regimen without mitomycin‐C. Since neither complete nor partial response rates, nor response durations improved with the addition of mitomycin, we conclude that it adds little to the efficacy of the other three agents.",
author = "Vogl, {Steven E.} and Harvey Lerner and Kaplan, {Barry H.} and Camacho, {Fernando J.} and James Cinberg and David Schoenfeld",
year = "1982",
month = "1",
day = "1",
doi = "10.1002/1097-0142(19820701)50:1<6::AID-CNCR2820500103>3.0.CO;2-H",
language = "English (US)",
volume = "50",
pages = "6--9",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Mitomycin‐C, methotrexate, bleomycin and cis‐diamminedichloroplatinum II in the chemotherapy of advanced squamous cancer of the head and neck

AU - Vogl, Steven E.

AU - Lerner, Harvey

AU - Kaplan, Barry H.

AU - Camacho, Fernando J.

AU - Cinberg, James

AU - Schoenfeld, David

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Thirty‐four patients with advanced squamous cancer of the head and neck were treated with an outpatient regimen combining mitomycin‐C, cis‐diamminedichloroplatinum (II), methotrexate and bleomycin. Five had complete remissions and 15 partial remissions, for an overall response rate of 59%. Responses were noted in 11 of 13 patients (85%) with disease above the clavicles without prior irradiation. Median duration of partial remission was four months. Response rate was independent of age, performance status, presence of distant metastases and primary site. Hematologic toxicity was substantially more severe with this program than had been observed in a prior study using the same regimen without mitomycin‐C. Since neither complete nor partial response rates, nor response durations improved with the addition of mitomycin, we conclude that it adds little to the efficacy of the other three agents.

AB - Thirty‐four patients with advanced squamous cancer of the head and neck were treated with an outpatient regimen combining mitomycin‐C, cis‐diamminedichloroplatinum (II), methotrexate and bleomycin. Five had complete remissions and 15 partial remissions, for an overall response rate of 59%. Responses were noted in 11 of 13 patients (85%) with disease above the clavicles without prior irradiation. Median duration of partial remission was four months. Response rate was independent of age, performance status, presence of distant metastases and primary site. Hematologic toxicity was substantially more severe with this program than had been observed in a prior study using the same regimen without mitomycin‐C. Since neither complete nor partial response rates, nor response durations improved with the addition of mitomycin, we conclude that it adds little to the efficacy of the other three agents.

UR - http://www.scopus.com/inward/record.url?scp=0019993789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019993789&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19820701)50:1<6::AID-CNCR2820500103>3.0.CO;2-H

DO - 10.1002/1097-0142(19820701)50:1<6::AID-CNCR2820500103>3.0.CO;2-H

M3 - Article

VL - 50

SP - 6

EP - 9

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 1

ER -