Mitomycin C for prevention of postoperative haze following excimer laser surface ablation in moderate to high myopia

Guilherme G. Quinto, Walter Camacho, Juan Castro Combs, Satyanarayana S. Vedula, Elliott H. Myrowitz, Roy S. Chuck

Research output: Contribution to journalArticle

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Primary objectives: The aim of this review is to evaluate the effects of MMC on the cornea and answer the question: is there sufficient evidence for using intraoperative topical MMC on the cornea in surface ablation (PRK or LASEK or epi-LASIK) as prophylaxis for haze formation and to reduce refractive regression? This review will address the use of MMC in the prophylaxis of myopic patients who underwent PRK or LASEK or epi-LASIK. Secondary objectives: If sufficient data are available, a secondary objective of this review is to determine the refractive predictability and complications with different concentrations and times of exposure to MMC as well as to find out if there are differences in proportion of patients with haze among different laser platforms used for PRK, LASEK, and epi-LASIK. Refractive predictability is defined as the difference between the attempted and achieved refractive change, in other words, the difference between the mean postoperative spherical equivalent (SE) and the target SE using the manifest refraction (Joo 2005).

Original languageEnglish (US)
Article numberCD007418
JournalCochrane Database of Systematic Reviews
Volume2016
Issue number10
DOIs
StatePublished - Oct 27 2016

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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