Mitogenic induction of macrophage and neutrophil proliferation in human tonsils

Julian Melamed, Arye Rubinstein

Research output: Contribution to journalArticlepeer-review


A spontaneous and mitogen-induced in vitro release of colony-stimulating activity from human tonsillar cells was observed. This release was absent when T cells were depleted from the cell suspension. Supernates containing colony-stimulating activity induced the proliferation and differentiation of tonsillar precursor cells into monocytes and granulocytes. The maturation and proliferation of monocytes and granulocytes were followed by a continuous flow staining technique, cytochemistry, electro-optical measurement, and signal logic processing employing the automated Hemalog D cell differential counter.

Original languageEnglish (US)
Pages (from-to)406-412
Number of pages7
JournalClinical Immunology and Immunopathology
Issue number4
StatePublished - Dec 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology


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