Mitogen-activated protein kinase pathways in interferon signaling.

Antonella Sassano, Amit K. Verma, Leonidas C. Platanias

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

There is recent evidence that in addition to the classic JAK/STAT pathways, mitogen-activated proteins (MAP) kinase pathways play important roles in Type I interferon signaling and the generation of interferon responses. In particular, the p38 MAP kinase cascade exerts positive regulatory roles on transciptional activation of interferon-sensitive genes (ISGs) and the induction of the antiproliferative and antiviral properties of interferons. In this chapter, methodologies to detect activation of p38 and various upstream and downstream effectors are provided. Also, the methodological approaches used to examine the role of this pathway on the regulation of hematopoiesis are discussed.

Original languageEnglish (US)
Pages (from-to)135-150
Number of pages16
JournalMethods in molecular medicine
Volume116
StatePublished - 2005
Externally publishedYes

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Mitogen-Activated Protein Kinases
Interferons
Interferon Type I
Hematopoiesis
p38 Mitogen-Activated Protein Kinases
Antiviral Agents
Genes

Cite this

Mitogen-activated protein kinase pathways in interferon signaling. / Sassano, Antonella; Verma, Amit K.; Platanias, Leonidas C.

In: Methods in molecular medicine, Vol. 116, 2005, p. 135-150.

Research output: Contribution to journalArticle

Sassano, Antonella ; Verma, Amit K. ; Platanias, Leonidas C. / Mitogen-activated protein kinase pathways in interferon signaling. In: Methods in molecular medicine. 2005 ; Vol. 116. pp. 135-150.
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