Mitochondrial Redox Dysfunction and Environmental Exposures

Samuel W. Caito, Michael Aschner

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Significance: Mitochondria are structurally and biochemically diverse, even within a single type of cell. Protein complexes localized to the inner mitochondrial membrane synthesize ATP by coupling electron transport and oxidative phosphorylation. The organelles produce reactive oxygen species (ROS) from mitochondrial oxygen and ROS can, in turn, alter the function and expression of proteins used for aerobic respiration by post-translational and transcriptional regulation. Recent Advances: New interest is emerging not only into the roles of mitochondria in disease development and progression but also as a target for environmental toxicants. Critical Issues: Dysregulation of respiration has been linked to cell death and is a major contributor to acute neuronal trauma, peripheral diseases, as well as chronic neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Future Directions: Here, we discuss the mechanisms underlying the sensitivity of the mitochondrial respiratory complexes to redox modulation, as well as examine the effects of environmental contaminants that have well-characterized mitochondrial toxicity. The contaminants discussed in this review are some of the most prevalent and potent environmental contaminants that have been linked to neurological dysfunction, altered cellular respiration, and oxidation.

Original languageEnglish (US)
Pages (from-to)578-595
Number of pages18
JournalAntioxidants and Redox Signaling
Volume23
Issue number6
DOIs
StatePublished - Aug 20 2015

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Environmental Exposure
Oxidation-Reduction
Reactive Oxygen Species
Mitochondria
Respiration
Impurities
Cell Respiration
Oxidative Phosphorylation
Mitochondrial Membranes
Electron Transport
Neurodegenerative Diseases
Organelles
Neurodegenerative diseases
Parkinson Disease
Disease Progression
Alzheimer Disease
Proteins
Chronic Disease
Cell Death
Adenosine Triphosphate

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Mitochondrial Redox Dysfunction and Environmental Exposures. / Caito, Samuel W.; Aschner, Michael.

In: Antioxidants and Redox Signaling, Vol. 23, No. 6, 20.08.2015, p. 578-595.

Research output: Contribution to journalArticle

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