Mitochondrial reactive oxygen species in the pathogenesis of early diabetic nephropathy

Takeshi Nishikawa, Michael Brownlee, Eiichi Araki

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Dugan et al. reported model of a feed-forward cycle involving decreased AMPK activity and decreased mitochondrial biogenesis caused by decreased ROS as a proposed mechanism involved in the pathogenesis of diabetic nephropathy. However, in this commentary, we proposed an alternate model of a feed-forward cycle involving decreased AMPK activity and decreased mitochondrial biogenesis caused by increased mitochondrial ROS.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalJournal of Diabetes Investigation
Volume6
Issue number2
DOIs
StatePublished - Mar 1 2015

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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