Mitochondrial matters: Mitochondrial bottlenecks, self-assembling structures, and entrapment in the female germline

Florence L. Marlow

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Mitochondrial replacement therapy, a procedure to generate embryos with the nuclear genome of a donor mother and the healthy mitochondria of a recipient egg, has recently emerged as a promising strategy to prevent transmission of devastating mitochondrial DNA diseases and infertility. The procedure may produce an embryo that is free of diseased mitochondria. A recent study addresses important fundamental questions about the mechanisms underlying maternal inheritance and translational questions regarding the transgenerational effectiveness of this promising therapeutic strategy. This review considers recent advances in our understanding of maternal inheritance of mitochondria, implications for fertility and mitochondrial disease, and potential roles for the Balbiani body, an ancient oocyte structure, in mitochondrial selection in oocytes, with emphasis on therapies to remedy mitochondrial disorders.

Original languageEnglish (US)
JournalStem Cell Research
DOIs
StateAccepted/In press - Aug 26 2016

Fingerprint

Mitochondrial Diseases
Mitochondria
Oocytes
Embryonic Structures
Mitochondrial DNA
Infertility
Ovum
Fertility
Genome
Therapeutics
Maternal Inheritance

ASJC Scopus subject areas

  • Medicine(all)
  • Developmental Biology
  • Cell Biology

Cite this

Mitochondrial matters : Mitochondrial bottlenecks, self-assembling structures, and entrapment in the female germline. / Marlow, Florence L.

In: Stem Cell Research, 26.08.2016.

Research output: Contribution to journalArticle

@article{69a3bcab03b44bddabaebbbf67eaf089,
title = "Mitochondrial matters: Mitochondrial bottlenecks, self-assembling structures, and entrapment in the female germline",
abstract = "Mitochondrial replacement therapy, a procedure to generate embryos with the nuclear genome of a donor mother and the healthy mitochondria of a recipient egg, has recently emerged as a promising strategy to prevent transmission of devastating mitochondrial DNA diseases and infertility. The procedure may produce an embryo that is free of diseased mitochondria. A recent study addresses important fundamental questions about the mechanisms underlying maternal inheritance and translational questions regarding the transgenerational effectiveness of this promising therapeutic strategy. This review considers recent advances in our understanding of maternal inheritance of mitochondria, implications for fertility and mitochondrial disease, and potential roles for the Balbiani body, an ancient oocyte structure, in mitochondrial selection in oocytes, with emphasis on therapies to remedy mitochondrial disorders.",
author = "Marlow, {Florence L.}",
year = "2016",
month = "8",
day = "26",
doi = "10.1016/j.scr.2017.03.004",
language = "English (US)",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",

}

TY - JOUR

T1 - Mitochondrial matters

T2 - Mitochondrial bottlenecks, self-assembling structures, and entrapment in the female germline

AU - Marlow, Florence L.

PY - 2016/8/26

Y1 - 2016/8/26

N2 - Mitochondrial replacement therapy, a procedure to generate embryos with the nuclear genome of a donor mother and the healthy mitochondria of a recipient egg, has recently emerged as a promising strategy to prevent transmission of devastating mitochondrial DNA diseases and infertility. The procedure may produce an embryo that is free of diseased mitochondria. A recent study addresses important fundamental questions about the mechanisms underlying maternal inheritance and translational questions regarding the transgenerational effectiveness of this promising therapeutic strategy. This review considers recent advances in our understanding of maternal inheritance of mitochondria, implications for fertility and mitochondrial disease, and potential roles for the Balbiani body, an ancient oocyte structure, in mitochondrial selection in oocytes, with emphasis on therapies to remedy mitochondrial disorders.

AB - Mitochondrial replacement therapy, a procedure to generate embryos with the nuclear genome of a donor mother and the healthy mitochondria of a recipient egg, has recently emerged as a promising strategy to prevent transmission of devastating mitochondrial DNA diseases and infertility. The procedure may produce an embryo that is free of diseased mitochondria. A recent study addresses important fundamental questions about the mechanisms underlying maternal inheritance and translational questions regarding the transgenerational effectiveness of this promising therapeutic strategy. This review considers recent advances in our understanding of maternal inheritance of mitochondria, implications for fertility and mitochondrial disease, and potential roles for the Balbiani body, an ancient oocyte structure, in mitochondrial selection in oocytes, with emphasis on therapies to remedy mitochondrial disorders.

UR - http://www.scopus.com/inward/record.url?scp=85015668357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015668357&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2017.03.004

DO - 10.1016/j.scr.2017.03.004

M3 - Article

AN - SCOPUS:85015668357

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

ER -