Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study

Howard D. Hosgood, Chin San Liu, Nathaniel Rothman, Stephanie J. Weinstein, Matthew R. Bonner, Min Shen, Unhee Lim, Jarmo Virtamo, Wen ling Cheng, Demetrius Albanes, Qing Lan

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Mitochondria are eukaryotic organelles responsible for energy production. Mitochondrial DNA (mtDNA) lack introns and protective histones, have limited DNA repair capacity and compensate for damage by increasing the number of mtDNA copies. As a consequence, mitochondria are more susceptible to reactive oxygen species, an important determinant of cancer risk, and it is hypothesized that increased mtDNA copy number may be associated with carcinogenesis. We assessed the association of mtDNA copy number and lung cancer risk in 227 prospectively collected cases and 227 matched controls from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age at randomization, smoking years and number of cigarettes smoked per day. There was suggestion of a dose-dependent relationship between mtDNA copy number and subsequent risk of lung cancer, with a prominent effect observed in the highest mtDNA copy number quartile [ORs (95% CI) by quartile: 1.0 (reference), 1.3 (0.7-2.5), 1.1 (0.6-2.2) and 2.4 (1.1-5.1); Ptrend = 0.008]. This is the first report, to the best of our knowledge, to suggest that mtDNA copy number may be positively associated with subsequent risk of lung cancer in a prospective cohort study; however, replication is needed in other studies and populations.

Original languageEnglish (US)
Pages (from-to)847-849
Number of pages3
JournalCarcinogenesis
Volume31
Issue number5
DOIs
StatePublished - Feb 22 2010
Externally publishedYes

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Mitochondrial DNA
Lung Neoplasms
Cohort Studies
Prospective Studies
Mitochondria
Odds Ratio
Confidence Intervals
beta Carotene
alpha-Tocopherol
Random Allocation
Tobacco Products
DNA Repair
Organelles
Histones
Introns
Reactive Oxygen Species
Neoplasms
Carcinogenesis
Logistic Models
Smoking

ASJC Scopus subject areas

  • Cancer Research

Cite this

Hosgood, H. D., Liu, C. S., Rothman, N., Weinstein, S. J., Bonner, M. R., Shen, M., ... Lan, Q. (2010). Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis, 31(5), 847-849. https://doi.org/10.1093/carcin/bgq045

Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. / Hosgood, Howard D.; Liu, Chin San; Rothman, Nathaniel; Weinstein, Stephanie J.; Bonner, Matthew R.; Shen, Min; Lim, Unhee; Virtamo, Jarmo; Cheng, Wen ling; Albanes, Demetrius; Lan, Qing.

In: Carcinogenesis, Vol. 31, No. 5, 22.02.2010, p. 847-849.

Research output: Contribution to journalArticle

Hosgood, HD, Liu, CS, Rothman, N, Weinstein, SJ, Bonner, MR, Shen, M, Lim, U, Virtamo, J, Cheng, WL, Albanes, D & Lan, Q 2010, 'Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study', Carcinogenesis, vol. 31, no. 5, pp. 847-849. https://doi.org/10.1093/carcin/bgq045
Hosgood, Howard D. ; Liu, Chin San ; Rothman, Nathaniel ; Weinstein, Stephanie J. ; Bonner, Matthew R. ; Shen, Min ; Lim, Unhee ; Virtamo, Jarmo ; Cheng, Wen ling ; Albanes, Demetrius ; Lan, Qing. / Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. In: Carcinogenesis. 2010 ; Vol. 31, No. 5. pp. 847-849.
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