Abstract
Mitochondria have long been recognized as ATP engines for the cell and recently as a dynamic and mobile organelles that control cell death and life. This exquisite organelle is the site of reactive oxygen species production and is highly vulnerable to exogenous stresses, resulting in catastrophic damage to the cell. Mitochondrial dysfunction is linked to a wide range of age-associated degenerative diseases, such as metabolic syndrome, cardiovascular disease, and neurodegenerative diseases. Understanding the molecular mechanisms of mitochondria-dependent pathogenesis may provide important strategies to treat these diseases. Indeed, mitochondria are emerging therapeutic targets for the mitochondria-related diseases. In this paper, we review the recent concepts of mitochondrial biology and how mitochondria are involved in ageassociated degenerative diseases. Furthermore, we summarize the therapeutics which target to improve mitochondrial functions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 235-245 |
| Number of pages | 11 |
| Journal | Biomolecules and Therapeutics |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1 2010 |
| Externally published | Yes |
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Keywords
- Degenerative disease
- Mitochondria
- Mitochondrial medicine
- Therapeutic
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Drug Discovery
Cite this
Mitochondria : The secret chamber of therapeutic targets for age-associated degenerative diseases. / Pak, Youngmi Kim; Jeong, Jae Hoon.
In: Biomolecules and Therapeutics, Vol. 18, No. 3, 01.07.2010, p. 235-245.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mitochondria
T2 - The secret chamber of therapeutic targets for age-associated degenerative diseases
AU - Pak, Youngmi Kim
AU - Jeong, Jae Hoon
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Mitochondria have long been recognized as ATP engines for the cell and recently as a dynamic and mobile organelles that control cell death and life. This exquisite organelle is the site of reactive oxygen species production and is highly vulnerable to exogenous stresses, resulting in catastrophic damage to the cell. Mitochondrial dysfunction is linked to a wide range of age-associated degenerative diseases, such as metabolic syndrome, cardiovascular disease, and neurodegenerative diseases. Understanding the molecular mechanisms of mitochondria-dependent pathogenesis may provide important strategies to treat these diseases. Indeed, mitochondria are emerging therapeutic targets for the mitochondria-related diseases. In this paper, we review the recent concepts of mitochondrial biology and how mitochondria are involved in ageassociated degenerative diseases. Furthermore, we summarize the therapeutics which target to improve mitochondrial functions.
AB - Mitochondria have long been recognized as ATP engines for the cell and recently as a dynamic and mobile organelles that control cell death and life. This exquisite organelle is the site of reactive oxygen species production and is highly vulnerable to exogenous stresses, resulting in catastrophic damage to the cell. Mitochondrial dysfunction is linked to a wide range of age-associated degenerative diseases, such as metabolic syndrome, cardiovascular disease, and neurodegenerative diseases. Understanding the molecular mechanisms of mitochondria-dependent pathogenesis may provide important strategies to treat these diseases. Indeed, mitochondria are emerging therapeutic targets for the mitochondria-related diseases. In this paper, we review the recent concepts of mitochondrial biology and how mitochondria are involved in ageassociated degenerative diseases. Furthermore, we summarize the therapeutics which target to improve mitochondrial functions.
KW - Degenerative disease
KW - Mitochondria
KW - Mitochondrial medicine
KW - Therapeutic
UR - http://www.scopus.com/inward/record.url?scp=77957372038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957372038&partnerID=8YFLogxK
U2 - 10.4062/biomolther.2010.18.3.235
DO - 10.4062/biomolther.2010.18.3.235
M3 - Review article
VL - 18
SP - 235
EP - 245
JO - Biomolecules and Therapeutics
JF - Biomolecules and Therapeutics
SN - 1976-9148
IS - 3
ER -