Mitochondria: The secret chamber of therapeutic targets for age-associated degenerative diseases

Youngmi Kim Pak, Jae Hoon Jeong

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Mitochondria have long been recognized as ATP engines for the cell and recently as a dynamic and mobile organelles that control cell death and life. This exquisite organelle is the site of reactive oxygen species production and is highly vulnerable to exogenous stresses, resulting in catastrophic damage to the cell. Mitochondrial dysfunction is linked to a wide range of age-associated degenerative diseases, such as metabolic syndrome, cardiovascular disease, and neurodegenerative diseases. Understanding the molecular mechanisms of mitochondria-dependent pathogenesis may provide important strategies to treat these diseases. Indeed, mitochondria are emerging therapeutic targets for the mitochondria-related diseases. In this paper, we review the recent concepts of mitochondrial biology and how mitochondria are involved in ageassociated degenerative diseases. Furthermore, we summarize the therapeutics which target to improve mitochondrial functions.

Original languageEnglish (US)
Pages (from-to)235-245
Number of pages11
JournalBiomolecules and Therapeutics
Volume18
Issue number3
DOIs
StatePublished - Jul 1 2010

Keywords

  • Degenerative disease
  • Mitochondria
  • Mitochondrial medicine
  • Therapeutic

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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