Mitochondria have Fe(III) receptors

J. Weaver, H. Zhan, S. Pollack

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Recent work has provided new evidence that ATP is the major constituent of the low-M(r) iron pool in the reticulocyte. The interaction of the iron complex of ATP with mitochondria was investigated in the present experiments. When ATP-Fe3+ was incubated with mitochondria, Fe3+, free of ATP, bound with high affinity to Fe3+ receptors on the mitochondria. The binding was saturable and reversible. Iron which was complexed to PP(i), nitrilotriacetate, citrate, ADP and GTP also showed saturable binding to mitochondria; Fe3+ complexed to AMP bound non-specifically, as did Fe2+/ascorbate and Fe2+/dithionite.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalBiochemical Journal
Volume265
Issue number2
DOIs
Publication statusPublished - Jan 1 1990

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Weaver, J., Zhan, H., & Pollack, S. (1990). Mitochondria have Fe(III) receptors. Biochemical Journal, 265(2), 415-419. https://doi.org/10.1042/bj2650415