Mitochondria have Fe(III) receptors

J. Weaver, H. Zhan, Simeon Pollack

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Recent work has provided new evidence that ATP is the major constituent of the low-M(r) iron pool in the reticulocyte. The interaction of the iron complex of ATP with mitochondria was investigated in the present experiments. When ATP-Fe3+ was incubated with mitochondria, Fe3+, free of ATP, bound with high affinity to Fe3+ receptors on the mitochondria. The binding was saturable and reversible. Iron which was complexed to PP(i), nitrilotriacetate, citrate, ADP and GTP also showed saturable binding to mitochondria; Fe3+ complexed to AMP bound non-specifically, as did Fe2+/ascorbate and Fe2+/dithionite.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalBiochemical Journal
Volume265
Issue number2
StatePublished - 1990

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Mitochondria
Adenosine Triphosphate
Iron
Dithionite
Reticulocytes
Adenosine Monophosphate
Guanosine Triphosphate
Citric Acid
Adenosine Diphosphate
Experiments

ASJC Scopus subject areas

  • Biochemistry

Cite this

Weaver, J., Zhan, H., & Pollack, S. (1990). Mitochondria have Fe(III) receptors. Biochemical Journal, 265(2), 415-419.

Mitochondria have Fe(III) receptors. / Weaver, J.; Zhan, H.; Pollack, Simeon.

In: Biochemical Journal, Vol. 265, No. 2, 1990, p. 415-419.

Research output: Contribution to journalArticle

Weaver, J, Zhan, H & Pollack, S 1990, 'Mitochondria have Fe(III) receptors', Biochemical Journal, vol. 265, no. 2, pp. 415-419.
Weaver, J. ; Zhan, H. ; Pollack, Simeon. / Mitochondria have Fe(III) receptors. In: Biochemical Journal. 1990 ; Vol. 265, No. 2. pp. 415-419.
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