TY - JOUR
T1 - Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases
AU - Giorgi, Carlotta
AU - Marchi, Saverio
AU - Simoes, Ines C.M.
AU - Ren, Ziyu
AU - Morciano, Giampaolo
AU - Perrone, Mariasole
AU - Patalas-Krawczyk, Paulina
AU - Borchard, Sabine
AU - Jędrak, Paulina
AU - Pierzynowska, Karolina
AU - Szymański, Jędrzej
AU - Wang, David Q.
AU - Portincasa, Piero
AU - Węgrzyn, Grzegorz
AU - Zischka, Hans
AU - Dobrzyn, Pawel
AU - Bonora, Massimo
AU - Duszynski, Jerzy
AU - Rimessi, Alessandro
AU - Karkucinska-Wieckowska, Agnieszka
AU - Dobrzyn, Agnieszka
AU - Szabadkai, Gyorgy
AU - Zavan, Barbara
AU - Oliveira, Paulo J.
AU - Sardao, Vilma A.
AU - Pinton, Paolo
AU - Wieckowski, Mariusz R.
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Aging has been linked to several degenerative processes that, through the accumulation of molecular and cellular damage, can progressively lead to cell dysfunction and organ failure. Human aging is linked with a higher risk for individuals to develop cancer, neurodegenerative, cardiovascular, and metabolic disorders. The understanding of the molecular basis of aging and associated diseases has been one major challenge of scientific research over the last decades. Mitochondria, the center of oxidative metabolism and principal site of reactive oxygen species (ROS) production, are crucial both in health and in pathogenesis of many diseases. Redox signaling is important for the modulation of cell functions and several studies indicate a dual role for ROS in cell physiology. In fact, high concentrations of ROS are pathogenic and can cause severe damage to cell and organelle membranes, DNA, and proteins. On the other hand, moderate amounts of ROS are essential for the maintenance of several biological processes, including gene expression. In this review, we provide an update regarding the key roles of ROS–mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging and highlighting that mitochondrial ROS may be a decisive target in clinical practice.
AB - Aging has been linked to several degenerative processes that, through the accumulation of molecular and cellular damage, can progressively lead to cell dysfunction and organ failure. Human aging is linked with a higher risk for individuals to develop cancer, neurodegenerative, cardiovascular, and metabolic disorders. The understanding of the molecular basis of aging and associated diseases has been one major challenge of scientific research over the last decades. Mitochondria, the center of oxidative metabolism and principal site of reactive oxygen species (ROS) production, are crucial both in health and in pathogenesis of many diseases. Redox signaling is important for the modulation of cell functions and several studies indicate a dual role for ROS in cell physiology. In fact, high concentrations of ROS are pathogenic and can cause severe damage to cell and organelle membranes, DNA, and proteins. On the other hand, moderate amounts of ROS are essential for the maintenance of several biological processes, including gene expression. In this review, we provide an update regarding the key roles of ROS–mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging and highlighting that mitochondrial ROS may be a decisive target in clinical practice.
KW - Age-related neurodegenerative disorders
KW - Aging
KW - Anti-ROS intervention
KW - Antioxidant defense
KW - Mitochondria
KW - Mitochondrial dysfunction–related pathologies
KW - ROS
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U2 - 10.1016/bs.ircmb.2018.05.006
DO - 10.1016/bs.ircmb.2018.05.006
M3 - Article
C2 - 30072092
AN - SCOPUS:85048861986
SN - 1937-6448
VL - 340
SP - 209
EP - 344
JO - International Review of Cell and Molecular Biology
JF - International Review of Cell and Molecular Biology
ER -