Missed non-small cell lung cancer

Radiographic findings of potentially resectable lesions evident only in retrospect

Priya Kumar Shah, John H M Austin, Charles S. White, Pavni Patel, Linda B. Haramati, Gregory D N Pearson, Maria C. Shiau, Yahya M. Berkmen

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

PURPOSE: To assess for change in the 1990s in the failure of detection at chest radiography of potentially resectable non-small cell lung cancer (NSCLC) lesions compared with experience in the previous decade. MATERIALS AND METHODS: From 1993 to 2001, an observational cohort was identified that consisted of 40 instances of NSCLC evident retrospectively at chest radiography but undetected by a radiologist at a time when the cancer was potentially resectable for cure. Sizes and locations of the tumors were assessed. Pearson X2 testing was performed to compare the sex distribution of lung cancer in the present series with population data for the sex distribution of lung cancer in the United States during the present study. RESULTS: Twenty-five (62%) undetected NSCLCs were in men and 15 (38%) were in women, yielding a ratio not significantly different from that for the sex distribution of NSCLC according to national data (X2 = 0.22, P = .64). Median patient age was 62 years (range, 37-87 years). Median diameter of the missed cancers was 1.9 cm. Missed cancers were most commonly located in the upper lobes (right, 45%; left, 28%; total, 72%), especially in the apical and posterior segments/subsegments (60% of all the missed cancers). A clavicle obscured 22% of the missed cancers. Eighty-five percent of the missed cancers were in peripheral locations. CONCLUSION: Potentially resectable NSCLC lesions missed at chest radiography were characterized by predominantly peripheral (85%) and upper lobe (72%) locations and by apical and posterior segmental/subsegmental locations in an upper lobe (60%). Distribution by sex of the missed cancers was comparable to national data for NSCLC. The missed cancers had a median diameter of 1.9 cm.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalRadiology
Volume226
Issue number1
DOIs
StatePublished - Jan 1 2003

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Non-Small Cell Lung Carcinoma
Sex Distribution
Neoplasms
Radiography
Thorax
Lung Neoplasms
Clavicle
Population

Keywords

  • Diagnostic radiology, observer performance
  • Lung neoplasms
  • Lung neoplasms, diagnosis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Shah, P. K., Austin, J. H. M., White, C. S., Patel, P., Haramati, L. B., Pearson, G. D. N., ... Berkmen, Y. M. (2003). Missed non-small cell lung cancer: Radiographic findings of potentially resectable lesions evident only in retrospect. Radiology, 226(1), 235-241. https://doi.org/10.1148/radiol.2261011924

Missed non-small cell lung cancer : Radiographic findings of potentially resectable lesions evident only in retrospect. / Shah, Priya Kumar; Austin, John H M; White, Charles S.; Patel, Pavni; Haramati, Linda B.; Pearson, Gregory D N; Shiau, Maria C.; Berkmen, Yahya M.

In: Radiology, Vol. 226, No. 1, 01.01.2003, p. 235-241.

Research output: Contribution to journalArticle

Shah, PK, Austin, JHM, White, CS, Patel, P, Haramati, LB, Pearson, GDN, Shiau, MC & Berkmen, YM 2003, 'Missed non-small cell lung cancer: Radiographic findings of potentially resectable lesions evident only in retrospect', Radiology, vol. 226, no. 1, pp. 235-241. https://doi.org/10.1148/radiol.2261011924
Shah, Priya Kumar ; Austin, John H M ; White, Charles S. ; Patel, Pavni ; Haramati, Linda B. ; Pearson, Gregory D N ; Shiau, Maria C. ; Berkmen, Yahya M. / Missed non-small cell lung cancer : Radiographic findings of potentially resectable lesions evident only in retrospect. In: Radiology. 2003 ; Vol. 226, No. 1. pp. 235-241.
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abstract = "PURPOSE: To assess for change in the 1990s in the failure of detection at chest radiography of potentially resectable non-small cell lung cancer (NSCLC) lesions compared with experience in the previous decade. MATERIALS AND METHODS: From 1993 to 2001, an observational cohort was identified that consisted of 40 instances of NSCLC evident retrospectively at chest radiography but undetected by a radiologist at a time when the cancer was potentially resectable for cure. Sizes and locations of the tumors were assessed. Pearson X2 testing was performed to compare the sex distribution of lung cancer in the present series with population data for the sex distribution of lung cancer in the United States during the present study. RESULTS: Twenty-five (62{\%}) undetected NSCLCs were in men and 15 (38{\%}) were in women, yielding a ratio not significantly different from that for the sex distribution of NSCLC according to national data (X2 = 0.22, P = .64). Median patient age was 62 years (range, 37-87 years). Median diameter of the missed cancers was 1.9 cm. Missed cancers were most commonly located in the upper lobes (right, 45{\%}; left, 28{\%}; total, 72{\%}), especially in the apical and posterior segments/subsegments (60{\%} of all the missed cancers). A clavicle obscured 22{\%} of the missed cancers. Eighty-five percent of the missed cancers were in peripheral locations. CONCLUSION: Potentially resectable NSCLC lesions missed at chest radiography were characterized by predominantly peripheral (85{\%}) and upper lobe (72{\%}) locations and by apical and posterior segmental/subsegmental locations in an upper lobe (60{\%}). Distribution by sex of the missed cancers was comparable to national data for NSCLC. The missed cancers had a median diameter of 1.9 cm.",
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AU - Berkmen, Yahya M.

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N2 - PURPOSE: To assess for change in the 1990s in the failure of detection at chest radiography of potentially resectable non-small cell lung cancer (NSCLC) lesions compared with experience in the previous decade. MATERIALS AND METHODS: From 1993 to 2001, an observational cohort was identified that consisted of 40 instances of NSCLC evident retrospectively at chest radiography but undetected by a radiologist at a time when the cancer was potentially resectable for cure. Sizes and locations of the tumors were assessed. Pearson X2 testing was performed to compare the sex distribution of lung cancer in the present series with population data for the sex distribution of lung cancer in the United States during the present study. RESULTS: Twenty-five (62%) undetected NSCLCs were in men and 15 (38%) were in women, yielding a ratio not significantly different from that for the sex distribution of NSCLC according to national data (X2 = 0.22, P = .64). Median patient age was 62 years (range, 37-87 years). Median diameter of the missed cancers was 1.9 cm. Missed cancers were most commonly located in the upper lobes (right, 45%; left, 28%; total, 72%), especially in the apical and posterior segments/subsegments (60% of all the missed cancers). A clavicle obscured 22% of the missed cancers. Eighty-five percent of the missed cancers were in peripheral locations. CONCLUSION: Potentially resectable NSCLC lesions missed at chest radiography were characterized by predominantly peripheral (85%) and upper lobe (72%) locations and by apical and posterior segmental/subsegmental locations in an upper lobe (60%). Distribution by sex of the missed cancers was comparable to national data for NSCLC. The missed cancers had a median diameter of 1.9 cm.

AB - PURPOSE: To assess for change in the 1990s in the failure of detection at chest radiography of potentially resectable non-small cell lung cancer (NSCLC) lesions compared with experience in the previous decade. MATERIALS AND METHODS: From 1993 to 2001, an observational cohort was identified that consisted of 40 instances of NSCLC evident retrospectively at chest radiography but undetected by a radiologist at a time when the cancer was potentially resectable for cure. Sizes and locations of the tumors were assessed. Pearson X2 testing was performed to compare the sex distribution of lung cancer in the present series with population data for the sex distribution of lung cancer in the United States during the present study. RESULTS: Twenty-five (62%) undetected NSCLCs were in men and 15 (38%) were in women, yielding a ratio not significantly different from that for the sex distribution of NSCLC according to national data (X2 = 0.22, P = .64). Median patient age was 62 years (range, 37-87 years). Median diameter of the missed cancers was 1.9 cm. Missed cancers were most commonly located in the upper lobes (right, 45%; left, 28%; total, 72%), especially in the apical and posterior segments/subsegments (60% of all the missed cancers). A clavicle obscured 22% of the missed cancers. Eighty-five percent of the missed cancers were in peripheral locations. CONCLUSION: Potentially resectable NSCLC lesions missed at chest radiography were characterized by predominantly peripheral (85%) and upper lobe (72%) locations and by apical and posterior segmental/subsegmental locations in an upper lobe (60%). Distribution by sex of the missed cancers was comparable to national data for NSCLC. The missed cancers had a median diameter of 1.9 cm.

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KW - Lung neoplasms, diagnosis

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