Mismatch negativity (MMN) as an index of cognitive dysfunction

Risto Näätänen, Elyse S. Sussman, Dean Salisbury, Valerie L. Shafer

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Cognition is often affected in a variety of neuropsychiatric, neurological, and neurodevelopmental disorders. The neural discriminative response, reflected in mismatch negativity (MMN) and its magnetoencephalographic equivalent (MMNm), has been used as a tool to study a variety of disorders involving auditory cognition. MMN/MMNm is an involuntary brain response to auditory change or, more generally, to pattern regularity violation. For a number of disorders, MMN/MMNm amplitude to sound deviance has been shown to be attenuated or the peak-latency of the component prolonged compared to controls. This general finding suggests that while not serving as a specific marker to any particular disorder, MMN may be useful for understanding factors of cognition in various disorders, and has potential to serve as an indicator of risk. This review presents a brief history of the MMN, followed by a description of how MMN has been used to index auditory processing capability in a range of neuropsychiatric, neurological, and neurodevelopmental disorders. Finally, we suggest future directions for research to further enhance our understanding of the neural substrate of deviance detection that could lead to improvements in the use of MMN as a clinical tool.

Original languageEnglish (US)
Pages (from-to)451-466
Number of pages16
JournalBrain Topography
Volume27
Issue number4
DOIs
StatePublished - 2014

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Cognition
Nervous System Diseases
Brain
Research
Cognitive Dysfunction
Neurodevelopmental Disorders
Direction compound

Keywords

  • Clinical application
  • Mismatch negativity (MMN)
  • Neurodevelopmental
  • Neurological
  • Neuropsychiatric

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Cite this

Mismatch negativity (MMN) as an index of cognitive dysfunction. / Näätänen, Risto; Sussman, Elyse S.; Salisbury, Dean; Shafer, Valerie L.

In: Brain Topography, Vol. 27, No. 4, 2014, p. 451-466.

Research output: Contribution to journalArticle

Näätänen, Risto ; Sussman, Elyse S. ; Salisbury, Dean ; Shafer, Valerie L. / Mismatch negativity (MMN) as an index of cognitive dysfunction. In: Brain Topography. 2014 ; Vol. 27, No. 4. pp. 451-466.
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