## Abstract

We provide a simple analytic correction for risk factor misclassification in a matched case-control study with variable numbers of controls per case. The method is an extension of existing methodology, and involves estimating the corrected proportions of controls and cases in risk factor categories within each matched set. These estimates are then used to calculate the Mantel-Haenszel odds ratio estimate corrected for misclassification. A simulation-based interval estimate is developed. An example is given from a study of risk factors for progression of benign breast disease to breast cancer, in which the risk factor is a biological marker measured with poor sensitivity.

Original language | English (US) |
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Pages (from-to) | 2459-2468 |

Number of pages | 10 |

Journal | Statistics in Medicine |

Volume | 22 |

Issue number | 15 |

DOIs | |

State | Published - Aug 15 2003 |

## Keywords

- Mantel-Haenszel estimate
- Markov chain Monte Carlo
- Matched case-control
- Misclassification

## ASJC Scopus subject areas

- Epidemiology
- Statistics and Probability