MiRNA-148b and its role in various cancers

Najmeh Dorraki; Zari Naderi Ghale-Noie; Nooshin Sadegh Ahmadi; Vahideh Keyvani; Rosita Azar Bahadori; Arash Salmani Nejad; Michael Aschner; Hossein Pourghadamyari; Samaneh Mollazadeh; Hamed Mirzaei

doi:10.2217/epi-2021-0155

MiRNA-148b and its role in various cancers

Najmeh Dorraki, Zari Naderi Ghale-Noie, Nooshin Sadegh Ahmadi, Vahideh Keyvani, Rosita Azar Bahadori, Arash Salmani Nejad, Michael Aschner, Hossein Pourghadamyari, Samaneh Mollazadeh, Hamed Mirzaei

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.

Original language	English (US)
Pages (from-to)	1939-1960
Number of pages	22
Journal	Epigenomics
Volume	13
Issue number	24
DOIs	https://doi.org/10.2217/epi-2021-0155
State	Published - Dec 2021

Keywords

biomarker
cancers
miR-148b
signaling pathway
target genes

ASJC Scopus subject areas

Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/epi-2021-0155

Cite this

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title = "MiRNA-148b and its role in various cancers",

abstract = "miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.",

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author = "Najmeh Dorraki and Ghale-Noie, {Zari Naderi} and Ahmadi, {Nooshin Sadegh} and Vahideh Keyvani and Bahadori, {Rosita Azar} and Nejad, {Arash Salmani} and Michael Aschner and Hossein Pourghadamyari and Samaneh Mollazadeh and Hamed Mirzaei",

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AU - Dorraki, Najmeh

AU - Ghale-Noie, Zari Naderi

AU - Ahmadi, Nooshin Sadegh

AU - Keyvani, Vahideh

AU - Bahadori, Rosita Azar

AU - Nejad, Arash Salmani

AU - Aschner, Michael

AU - Pourghadamyari, Hossein

AU - Mollazadeh, Samaneh

AU - Mirzaei, Hamed

PY - 2021/12

Y1 - 2021/12

N2 - miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.

AB - miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.

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KW - cancers

KW - miR-148b

KW - signaling pathway

KW - target genes

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MiRNA-148b and its role in various cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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