MiRNA-148b and its role in various cancers

Najmeh Dorraki, Zari Naderi Ghale-Noie, Nooshin Sadegh Ahmadi, Vahideh Keyvani, Rosita Azar Bahadori, Arash Salmani Nejad, Michael Aschner, Hossein Pourghadamyari, Samaneh Mollazadeh, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.

Original languageEnglish (US)
Pages (from-to)1939-1960
Number of pages22
JournalEpigenomics
Volume13
Issue number24
DOIs
StatePublished - Dec 2021

Keywords

  • biomarker
  • cancers
  • miR-148b
  • signaling pathway
  • target genes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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