MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2

Chunliang Xu, Guangwen Ren, Gang Cao, Qing Chen, Peishun Shou, Chunxing Zheng, Liming Du, Xiaoyan Han, Menghui Jiang, Qian Yang, Liangyu Lin, Guan Wang, Pengfei Yu, Xin Zhang, Wei Cao, Gary Brewer, Ying Wang, Yufang Shi

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: The molecular mechanisms underlining the immune regulatory property of mesenchymal stem cells (MSCs) are unknown. Results: Inflammatory cytokine-induced miR-155 reverses the immunosuppressive capacity of MSCs through inhibiting iNOS expression. Conclusion: The immune regulation-mediated by MSCs is tightly regulated by miR-155. Significance: This study revealed a novel role of miR-155 in regulating the immune modulatory activities of MSCs.

Original languageEnglish (US)
Pages (from-to)11074-11079
Number of pages6
JournalJournal of Biological Chemistry
Volume288
Issue number16
DOIs
StatePublished - Apr 19 2013
Externally publishedYes

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Stem cells
Mesenchymal Stromal Cells
Carrier Proteins
Immunosuppressive Agents
Cytokines

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. / Xu, Chunliang; Ren, Guangwen; Cao, Gang; Chen, Qing; Shou, Peishun; Zheng, Chunxing; Du, Liming; Han, Xiaoyan; Jiang, Menghui; Yang, Qian; Lin, Liangyu; Wang, Guan; Yu, Pengfei; Zhang, Xin; Cao, Wei; Brewer, Gary; Wang, Ying; Shi, Yufang.

In: Journal of Biological Chemistry, Vol. 288, No. 16, 19.04.2013, p. 11074-11079.

Research output: Contribution to journalArticle

Xu, C, Ren, G, Cao, G, Chen, Q, Shou, P, Zheng, C, Du, L, Han, X, Jiang, M, Yang, Q, Lin, L, Wang, G, Yu, P, Zhang, X, Cao, W, Brewer, G, Wang, Y & Shi, Y 2013, 'MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2', Journal of Biological Chemistry, vol. 288, no. 16, pp. 11074-11079. https://doi.org/10.1074/jbc.M112.414862
Xu, Chunliang ; Ren, Guangwen ; Cao, Gang ; Chen, Qing ; Shou, Peishun ; Zheng, Chunxing ; Du, Liming ; Han, Xiaoyan ; Jiang, Menghui ; Yang, Qian ; Lin, Liangyu ; Wang, Guan ; Yu, Pengfei ; Zhang, Xin ; Cao, Wei ; Brewer, Gary ; Wang, Ying ; Shi, Yufang. / MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 16. pp. 11074-11079.
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abstract = "Background: The molecular mechanisms underlining the immune regulatory property of mesenchymal stem cells (MSCs) are unknown. Results: Inflammatory cytokine-induced miR-155 reverses the immunosuppressive capacity of MSCs through inhibiting iNOS expression. Conclusion: The immune regulation-mediated by MSCs is tightly regulated by miR-155. Significance: This study revealed a novel role of miR-155 in regulating the immune modulatory activities of MSCs.",
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AU - Cao, Gang

AU - Chen, Qing

AU - Shou, Peishun

AU - Zheng, Chunxing

AU - Du, Liming

AU - Han, Xiaoyan

AU - Jiang, Menghui

AU - Yang, Qian

AU - Lin, Liangyu

AU - Wang, Guan

AU - Yu, Pengfei

AU - Zhang, Xin

AU - Cao, Wei

AU - Brewer, Gary

AU - Wang, Ying

AU - Shi, Yufang

PY - 2013/4/19

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