Abstract
Background: The molecular mechanisms underlining the immune regulatory property of mesenchymal stem cells (MSCs) are unknown. Results: Inflammatory cytokine-induced miR-155 reverses the immunosuppressive capacity of MSCs through inhibiting iNOS expression. Conclusion: The immune regulation-mediated by MSCs is tightly regulated by miR-155. Significance: This study revealed a novel role of miR-155 in regulating the immune modulatory activities of MSCs.
Original language | English (US) |
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Pages (from-to) | 11074-11079 |
Number of pages | 6 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 16 |
DOIs | |
State | Published - Apr 19 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology