MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2

Chunliang Xu, Guangwen Ren, Gang Cao, Qing Chen, Peishun Shou, Chunxing Zheng, Liming Du, Xiaoyan Han, Menghui Jiang, Qian Yang, Liangyu Lin, Guan Wang, Pengfei Yu, Xin Zhang, Wei Cao, Gary Brewer, Ying Wang, Yufang Shi

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Background: The molecular mechanisms underlining the immune regulatory property of mesenchymal stem cells (MSCs) are unknown. Results: Inflammatory cytokine-induced miR-155 reverses the immunosuppressive capacity of MSCs through inhibiting iNOS expression. Conclusion: The immune regulation-mediated by MSCs is tightly regulated by miR-155. Significance: This study revealed a novel role of miR-155 in regulating the immune modulatory activities of MSCs.

Original languageEnglish (US)
Pages (from-to)11074-11079
Number of pages6
JournalJournal of Biological Chemistry
Volume288
Issue number16
DOIs
StatePublished - Apr 19 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Xu, C., Ren, G., Cao, G., Chen, Q., Shou, P., Zheng, C., Du, L., Han, X., Jiang, M., Yang, Q., Lin, L., Wang, G., Yu, P., Zhang, X., Cao, W., Brewer, G., Wang, Y., & Shi, Y. (2013). MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2. Journal of Biological Chemistry, 288(16), 11074-11079. https://doi.org/10.1074/jbc.M112.414862