Minoxidil and pericardial effusion: An idiosyncratic reaction

Research output: Contribution to journalArticle

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Abstract

Minoxidil is a new potent antihypertensive vasodilator. Although highly effective, its use is limited by the association of the drug with pericardial effusion. We examined possible relationships in 37 patients. There were two significant effusions identified by echocardiography in 22 patients under active treatment. Retrospective review of 15 additional patients no longer under treatment identified seven who had had effusion and one who had had transient pericarditis. Resolution of effusion accompanied withdrawal in five patients; rechallenge was followed by effusion in one patient. Ninety-one episodes of pericardial disease have been reported in 1,869 experimental subjects (4.8%). Pericardial tamponade occurred in 21, with eight associated deaths. There are no specific patient characteristics that predict the likelihood of effusion. Since the reaction is both idiosyncratic and potentially fatal, it seems appropriate to continue to limit the use of minoxidil.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume30
Issue number1
StatePublished - Jul 1981
Externally publishedYes

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Minoxidil
Pericardial Effusion
Cardiac Tamponade
Pericarditis
Vasodilator Agents
Antihypertensive Agents
Echocardiography
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Minoxidil and pericardial effusion : An idiosyncratic reaction. / Reichgott, Michael J.

In: Clinical Pharmacology and Therapeutics, Vol. 30, No. 1, 07.1981, p. 64-70.

Research output: Contribution to journalArticle

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