Minireview

Mechanisms of growth hormone- mediated gene regulation

Dennis J. Chia

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

GH exerts a diverse array of physiological actions that include prominent roles in growth and metabolism, with a major contribution via stimulating IGF-1 synthesis. GH achieves its effects by influencing gene expression profiles, and Igf1 is a key transcriptional target ofGHsignaling in liver and other tissues. This review examines the mechanisms of GH-mediated gene regulation that begin with signal transduction pathways activated downstream of the GH receptor and continue with chromatin events at target genes and additionally encompasses the topics of negative regulation and cross talk with other cellular inputs. The transcription factor, signal transducer and activator of transcription 5b, is regarded as the major signaling pathway by which GH achieves its physiological effects, including in stimulating Igf1 gene transcription in liver. Recent studies exploring the mechanisms of how activated signal transducer and activator of transcription 5b accomplishes this are highlighted, which begin to characterize epigenetic features at regulatory domains of the Igf1 locus. Further research in this field offers promise to better understand the GH-IGF-1 axis in normal physiology and disease and to identify strategies to manipulate the axis to improve human health.

Original languageEnglish (US)
Pages (from-to)1012-1025
Number of pages14
JournalMolecular Endocrinology
Volume28
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

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STAT5 Transcription Factor
Growth Hormone
Insulin-Like Growth Factor I
Genes
Liver
Transcriptome
Epigenomics
Chromatin
Signal Transduction
Transcription Factors
Health
Growth
Research

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology
  • Medicine(all)

Cite this

Minireview : Mechanisms of growth hormone- mediated gene regulation. / Chia, Dennis J.

In: Molecular Endocrinology, Vol. 28, No. 7, 2014, p. 1012-1025.

Research output: Contribution to journalArticle

Chia, Dennis J. / Minireview : Mechanisms of growth hormone- mediated gene regulation. In: Molecular Endocrinology. 2014 ; Vol. 28, No. 7. pp. 1012-1025.
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