Mining the epigenetic landscape in ALL

Lindsay M. Lafave, Ross L. Levine

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.

Original languageEnglish (US)
Pages (from-to)1269-1270
Number of pages2
JournalNature Genetics
Volume45
Issue number11
DOIs
StatePublished - Nov 2013
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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