Mini-review: Presentation of pathogen-derived antigens in vivo

Gregoire Lauvau, Nicolas Glaichenhaus

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Most intracellular pathogens induce robust T cell responses upon infection of mammalian hosts. In most cases, these T cell responses are protective and result in pathogen clearance. It is therefore important to determine how T cells are primed and how they differentiate into cytokine-secreting and/or cytotoxic effector cells. In contrast to B cells, which recognize soluble Ag, CD8+ and CD4+T cells react to Ag-derived peptides bound to MHC I or MHC II molecules, respectively. Therefore, elucidating the mechanisms by which pathogen-derived Ag become available for presentation is necessary to understand how pathogens trigger T cell responses in vivo. Although many excellent reviews have focused on the mechanisms involved in Ag processing, very few have pointed to the specificity of host-pathogen interactions. In this respect, it should be noticed that these interactions are very different from one pathogen to another, and may result in the involvement of different cells and molecules. Because of space limitations, we have decided to focus this review on two intracellular pathogens - vaccinia virus and Listeria monocytogenes. We have chosen these two pathogens because they both induce a strong CD8+ T cell response and because they have been extensively studied by both microbiologists and immunologists.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalEuropean Journal of Immunology
Volume34
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

T-Lymphocytes
Antigens
Host-Pathogen Interactions
Vaccinia virus
Listeria monocytogenes
B-Lymphocytes
Cytokines
Peptides
Infection

Keywords

  • Antigen presentation
  • Dendritic cell
  • Listeria monocytogenes
  • T lymphocyte
  • Vaccinia

ASJC Scopus subject areas

  • Immunology

Cite this

Mini-review : Presentation of pathogen-derived antigens in vivo. / Lauvau, Gregoire; Glaichenhaus, Nicolas.

In: European Journal of Immunology, Vol. 34, No. 4, 04.2004, p. 913-920.

Research output: Contribution to journalArticle

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