Miller Fisher syndrome: Axonal, demyelinating or both?

S. N. Scelsa, S. Herskovitz

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Controversy exists concerning whether Miller Fisher syndrome (MFS) is the result of a predominantly axonal or demyelinating polyneuropathy and whether the Guillain-Barré syndrome variant of acute ataxia and areflexia without ophthalmoplegia, ataxic Guillain-Barré syndrome (atxGBS), has a distinct pathophysiology. We explored these issues by reviewing the electrophysiologic features of 6 patients with MFS and 2 patients with atxGBS. EMG laboratory records were reviewed and electrophysiologic findings were categorized as axonal or demyelinating neuropathy using previously defined criteria. Of the 6 patients with MFS, 5 had electrophysiologic evidence suggestive of an axonal, predominantly sensory polyneuropathy; only 1 patient met criteria for demyelinating polyneuropathy. Both patients with atxGBS had demyelinating sensorimotor polyneuropathy. Electrophysiologic abnormalities in MFS typically suggest a predominantly axonal, sensory polyneuropathy, though demyelinating forms occur and may be under-diagnosed using current criteria, AtxGBS, in our experience, is a predominantly demyelinating polyneuropathy.

Original languageEnglish (US)
Pages (from-to)497-502
Number of pages6
JournalElectromyography and Clinical Neurophysiology
Volume40
Issue number8
StatePublished - 2000
Externally publishedYes

Keywords

  • Ataxia
  • Electrophysiology
  • Guillain-Barré syndrome
  • Lyme disease
  • Miller Fisher syndrome

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Physiology (medical)

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