Miller-Dieker syndrome

A disorder affecting specific pathways of neuronal migration

L. A. Alvarez, T. Yamamoto, B. Wong, T. J. Resnick, J. F. Llena, Solomon L. Moshe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A patient with the typical craniofacial features and clinical course of Miller-Dieker syndrome (MDS) was found on autopsy to have focal pachygyria rather than lissencephaly. The brainstem and cerebellum were hypoplastic, but thalami and basal ganglia were normal. We believe that MDS is a syndrome in which multiple specific pathways of neuronal migration are affected selectively, such as migration to the neocortex, migration via corpus pontobulbare, and cerebellar migration. However, another migration pathway (via corpus gangliothalamicum) is spared.

Original languageEnglish (US)
Pages (from-to)489-493
Number of pages5
JournalNeurology
Volume36
Issue number4
StatePublished - 1986
Externally publishedYes

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Classical Lissencephalies and Subcortical Band Heterotopias
Lissencephaly
Neocortex
Basal Ganglia
Thalamus
Cerebellum
Brain Stem
Autopsy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alvarez, L. A., Yamamoto, T., Wong, B., Resnick, T. J., Llena, J. F., & Moshe, S. L. (1986). Miller-Dieker syndrome: A disorder affecting specific pathways of neuronal migration. Neurology, 36(4), 489-493.

Miller-Dieker syndrome : A disorder affecting specific pathways of neuronal migration. / Alvarez, L. A.; Yamamoto, T.; Wong, B.; Resnick, T. J.; Llena, J. F.; Moshe, Solomon L.

In: Neurology, Vol. 36, No. 4, 1986, p. 489-493.

Research output: Contribution to journalArticle

Alvarez, LA, Yamamoto, T, Wong, B, Resnick, TJ, Llena, JF & Moshe, SL 1986, 'Miller-Dieker syndrome: A disorder affecting specific pathways of neuronal migration', Neurology, vol. 36, no. 4, pp. 489-493.
Alvarez LA, Yamamoto T, Wong B, Resnick TJ, Llena JF, Moshe SL. Miller-Dieker syndrome: A disorder affecting specific pathways of neuronal migration. Neurology. 1986;36(4):489-493.
Alvarez, L. A. ; Yamamoto, T. ; Wong, B. ; Resnick, T. J. ; Llena, J. F. ; Moshe, Solomon L. / Miller-Dieker syndrome : A disorder affecting specific pathways of neuronal migration. In: Neurology. 1986 ; Vol. 36, No. 4. pp. 489-493.
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