Miller-Dieker syndrome: A disorder affecting specific pathways of neuronal migration

L. A. Alvarez, T. Yamamoto, B. Wong, T. J. Resnick, J. F. Llena, S. L. Moshé

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A patient with the typical craniofacial features and clinical course of Miller-Dieker syndrome (MDS) was found on autopsy to have focal pachygyria rather than lissencephaly. The brainstem and cerebellum were hypoplastic, but thalami and basal ganglia were normal. We believe that MDS is a syndrome in which multiple specific pathways of neuronal migration are affected selectively, such as migration to the neocortex, migration via corpus pontobulbare, and cerebellar migration. However, another migration pathway (via corpus gangliothalamicum) is spared.

Original languageEnglish (US)
Pages (from-to)489-493
Number of pages5
JournalNeurology
Volume36
Issue number4
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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