Midbrain serotonergic neurons are central pH chemoreceptors

Christopher A. Severson, Wengang Wang, Vincent A. Pieribone, Carolin I. Dohle, George B. Richerson

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Serotonergic neurons in the medulla are central respiratory chemoreceptors. Here we show that serotonergic neurons in the midbrain of rats are also highly chemosensitive to small changes in CO2/pH and are closely associated with large penetrating arteries. We propose that midbrain raphé neurons are sensors of blood CO2 that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis.

Original languageEnglish (US)
Pages (from-to)1139-1140
Number of pages2
JournalNature Neuroscience
Volume6
Issue number11
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

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Serotonergic Neurons
Mesencephalon
Respiratory Acidosis
Arousal
Homeostasis
Anxiety
Arteries
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Severson, C. A., Wang, W., Pieribone, V. A., Dohle, C. I., & Richerson, G. B. (2003). Midbrain serotonergic neurons are central pH chemoreceptors. Nature Neuroscience, 6(11), 1139-1140. https://doi.org/10.1038/nn1130

Midbrain serotonergic neurons are central pH chemoreceptors. / Severson, Christopher A.; Wang, Wengang; Pieribone, Vincent A.; Dohle, Carolin I.; Richerson, George B.

In: Nature Neuroscience, Vol. 6, No. 11, 01.11.2003, p. 1139-1140.

Research output: Contribution to journalArticle

Severson, CA, Wang, W, Pieribone, VA, Dohle, CI & Richerson, GB 2003, 'Midbrain serotonergic neurons are central pH chemoreceptors', Nature Neuroscience, vol. 6, no. 11, pp. 1139-1140. https://doi.org/10.1038/nn1130
Severson CA, Wang W, Pieribone VA, Dohle CI, Richerson GB. Midbrain serotonergic neurons are central pH chemoreceptors. Nature Neuroscience. 2003 Nov 1;6(11):1139-1140. https://doi.org/10.1038/nn1130
Severson, Christopher A. ; Wang, Wengang ; Pieribone, Vincent A. ; Dohle, Carolin I. ; Richerson, George B. / Midbrain serotonergic neurons are central pH chemoreceptors. In: Nature Neuroscience. 2003 ; Vol. 6, No. 11. pp. 1139-1140.
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